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Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children

BACKGROUND: Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. HMGA2 is a proto-oncogene with increased expression in various malignancies. METHODS: We explored the association of HMGA2 polymorphisms with glioma susceptibility in Chinese children using...

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Autores principales: Zhou, Jingying, Wang, Pan, Zhang, Ran, Huang, Xiaokai, Dai, Hanqi, Yuan, Li, Ruan, Jichen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164710/
https://www.ncbi.nlm.nih.gov/pubmed/34079335
http://dx.doi.org/10.2147/PGPM.S310780
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author Zhou, Jingying
Wang, Pan
Zhang, Ran
Huang, Xiaokai
Dai, Hanqi
Yuan, Li
Ruan, Jichen
author_facet Zhou, Jingying
Wang, Pan
Zhang, Ran
Huang, Xiaokai
Dai, Hanqi
Yuan, Li
Ruan, Jichen
author_sort Zhou, Jingying
collection PubMed
description BACKGROUND: Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. HMGA2 is a proto-oncogene with increased expression in various malignancies. METHODS: We explored the association of HMGA2 polymorphisms with glioma susceptibility in Chinese children using a case-control study (191 cases, 248 controls). HMGA2 single nucleotide polymorphisms (rs6581658 A>G; rs8756 A>C; rs968697 T>C) were genotyped using PCR-based TaqMan. RESULTS: Increased glioma susceptibility was associated with rs6581658 A>G; AG (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.13–2.58, P = 0.010) or GG (adjusted OR = 3.12, 95% CI = 1.26–7.74, P = 0.014) genotype carriers had significantly raised glioma risk compared with AA genotype carriers. The rs6581658 AG/GG (adjusted OR = 1.85, 95% CI = 1.25–2.73, P = 0.002) and AA/GG (adjusted OR = 2.58, 95% CI = 1.05–6.33, P = 0.038) genotypes were associated with an increased risk of glioma relative to the AA genotype. Subjects with 2–3 risk genotypes had a significantly elevated risk (adjusted OR = 1.93, 95% CI = 1.31–2.84, P = 0.001) relative to those with 0–1 risk genotype. CONCLUSION: HMGA2 rs6581658 A>G is associated with glioma susceptibility in Chinese children.
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spelling pubmed-81647102021-06-01 Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children Zhou, Jingying Wang, Pan Zhang, Ran Huang, Xiaokai Dai, Hanqi Yuan, Li Ruan, Jichen Pharmgenomics Pers Med Original Research BACKGROUND: Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. HMGA2 is a proto-oncogene with increased expression in various malignancies. METHODS: We explored the association of HMGA2 polymorphisms with glioma susceptibility in Chinese children using a case-control study (191 cases, 248 controls). HMGA2 single nucleotide polymorphisms (rs6581658 A>G; rs8756 A>C; rs968697 T>C) were genotyped using PCR-based TaqMan. RESULTS: Increased glioma susceptibility was associated with rs6581658 A>G; AG (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.13–2.58, P = 0.010) or GG (adjusted OR = 3.12, 95% CI = 1.26–7.74, P = 0.014) genotype carriers had significantly raised glioma risk compared with AA genotype carriers. The rs6581658 AG/GG (adjusted OR = 1.85, 95% CI = 1.25–2.73, P = 0.002) and AA/GG (adjusted OR = 2.58, 95% CI = 1.05–6.33, P = 0.038) genotypes were associated with an increased risk of glioma relative to the AA genotype. Subjects with 2–3 risk genotypes had a significantly elevated risk (adjusted OR = 1.93, 95% CI = 1.31–2.84, P = 0.001) relative to those with 0–1 risk genotype. CONCLUSION: HMGA2 rs6581658 A>G is associated with glioma susceptibility in Chinese children. Dove 2021-05-25 /pmc/articles/PMC8164710/ /pubmed/34079335 http://dx.doi.org/10.2147/PGPM.S310780 Text en © 2021 Zhou et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhou, Jingying
Wang, Pan
Zhang, Ran
Huang, Xiaokai
Dai, Hanqi
Yuan, Li
Ruan, Jichen
Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children
title Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children
title_full Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children
title_fullStr Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children
title_full_unstemmed Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children
title_short Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children
title_sort association of hmga2 polymorphisms with glioma susceptibility in chinese children
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164710/
https://www.ncbi.nlm.nih.gov/pubmed/34079335
http://dx.doi.org/10.2147/PGPM.S310780
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