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Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children
BACKGROUND: Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. HMGA2 is a proto-oncogene with increased expression in various malignancies. METHODS: We explored the association of HMGA2 polymorphisms with glioma susceptibility in Chinese children using...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164710/ https://www.ncbi.nlm.nih.gov/pubmed/34079335 http://dx.doi.org/10.2147/PGPM.S310780 |
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author | Zhou, Jingying Wang, Pan Zhang, Ran Huang, Xiaokai Dai, Hanqi Yuan, Li Ruan, Jichen |
author_facet | Zhou, Jingying Wang, Pan Zhang, Ran Huang, Xiaokai Dai, Hanqi Yuan, Li Ruan, Jichen |
author_sort | Zhou, Jingying |
collection | PubMed |
description | BACKGROUND: Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. HMGA2 is a proto-oncogene with increased expression in various malignancies. METHODS: We explored the association of HMGA2 polymorphisms with glioma susceptibility in Chinese children using a case-control study (191 cases, 248 controls). HMGA2 single nucleotide polymorphisms (rs6581658 A>G; rs8756 A>C; rs968697 T>C) were genotyped using PCR-based TaqMan. RESULTS: Increased glioma susceptibility was associated with rs6581658 A>G; AG (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.13–2.58, P = 0.010) or GG (adjusted OR = 3.12, 95% CI = 1.26–7.74, P = 0.014) genotype carriers had significantly raised glioma risk compared with AA genotype carriers. The rs6581658 AG/GG (adjusted OR = 1.85, 95% CI = 1.25–2.73, P = 0.002) and AA/GG (adjusted OR = 2.58, 95% CI = 1.05–6.33, P = 0.038) genotypes were associated with an increased risk of glioma relative to the AA genotype. Subjects with 2–3 risk genotypes had a significantly elevated risk (adjusted OR = 1.93, 95% CI = 1.31–2.84, P = 0.001) relative to those with 0–1 risk genotype. CONCLUSION: HMGA2 rs6581658 A>G is associated with glioma susceptibility in Chinese children. |
format | Online Article Text |
id | pubmed-8164710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-81647102021-06-01 Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children Zhou, Jingying Wang, Pan Zhang, Ran Huang, Xiaokai Dai, Hanqi Yuan, Li Ruan, Jichen Pharmgenomics Pers Med Original Research BACKGROUND: Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. HMGA2 is a proto-oncogene with increased expression in various malignancies. METHODS: We explored the association of HMGA2 polymorphisms with glioma susceptibility in Chinese children using a case-control study (191 cases, 248 controls). HMGA2 single nucleotide polymorphisms (rs6581658 A>G; rs8756 A>C; rs968697 T>C) were genotyped using PCR-based TaqMan. RESULTS: Increased glioma susceptibility was associated with rs6581658 A>G; AG (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.13–2.58, P = 0.010) or GG (adjusted OR = 3.12, 95% CI = 1.26–7.74, P = 0.014) genotype carriers had significantly raised glioma risk compared with AA genotype carriers. The rs6581658 AG/GG (adjusted OR = 1.85, 95% CI = 1.25–2.73, P = 0.002) and AA/GG (adjusted OR = 2.58, 95% CI = 1.05–6.33, P = 0.038) genotypes were associated with an increased risk of glioma relative to the AA genotype. Subjects with 2–3 risk genotypes had a significantly elevated risk (adjusted OR = 1.93, 95% CI = 1.31–2.84, P = 0.001) relative to those with 0–1 risk genotype. CONCLUSION: HMGA2 rs6581658 A>G is associated with glioma susceptibility in Chinese children. Dove 2021-05-25 /pmc/articles/PMC8164710/ /pubmed/34079335 http://dx.doi.org/10.2147/PGPM.S310780 Text en © 2021 Zhou et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Zhou, Jingying Wang, Pan Zhang, Ran Huang, Xiaokai Dai, Hanqi Yuan, Li Ruan, Jichen Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children |
title | Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children |
title_full | Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children |
title_fullStr | Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children |
title_full_unstemmed | Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children |
title_short | Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children |
title_sort | association of hmga2 polymorphisms with glioma susceptibility in chinese children |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164710/ https://www.ncbi.nlm.nih.gov/pubmed/34079335 http://dx.doi.org/10.2147/PGPM.S310780 |
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