Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine

The authors evaluated the presence of paclitaxel and healing of distal hind limb wounds created in 27 swine using biopsy punches followed by paclitaxel-coated balloon (PCB) use in the iliofemoral arteries of healthy swine. After 14 and 28 days, no differences were seen in time course, appearance, an...

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Autores principales: Granada, Juan F., Ferrone, Marco, Melnick, Gilberto, Crookall, Lesley, Schulz-Jander, Daniel, Tunev, Stefan, Melder, Robert J., Kaluza, Grzegorz L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165120/
https://www.ncbi.nlm.nih.gov/pubmed/34095632
http://dx.doi.org/10.1016/j.jacbts.2021.01.012
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author Granada, Juan F.
Ferrone, Marco
Melnick, Gilberto
Crookall, Lesley
Schulz-Jander, Daniel
Tunev, Stefan
Melder, Robert J.
Kaluza, Grzegorz L.
author_facet Granada, Juan F.
Ferrone, Marco
Melnick, Gilberto
Crookall, Lesley
Schulz-Jander, Daniel
Tunev, Stefan
Melder, Robert J.
Kaluza, Grzegorz L.
author_sort Granada, Juan F.
collection PubMed
description The authors evaluated the presence of paclitaxel and healing of distal hind limb wounds created in 27 swine using biopsy punches followed by paclitaxel-coated balloon (PCB) use in the iliofemoral arteries of healthy swine. After 14 and 28 days, no differences were seen in time course, appearance, and histopathology of wound healing between the single or triple PCB and uncoated balloon treatment despite clinically relevant paclitaxel concentrations in the skin adjacent to the healing wounds. Presence of paclitaxel downstream from the PCB treatment site does not impair the wound healing response of preexisting distal cutaneous lesions in healthy swine.
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spelling pubmed-81651202021-06-05 Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine Granada, Juan F. Ferrone, Marco Melnick, Gilberto Crookall, Lesley Schulz-Jander, Daniel Tunev, Stefan Melder, Robert J. Kaluza, Grzegorz L. JACC Basic Transl Sci Preclinical Research The authors evaluated the presence of paclitaxel and healing of distal hind limb wounds created in 27 swine using biopsy punches followed by paclitaxel-coated balloon (PCB) use in the iliofemoral arteries of healthy swine. After 14 and 28 days, no differences were seen in time course, appearance, and histopathology of wound healing between the single or triple PCB and uncoated balloon treatment despite clinically relevant paclitaxel concentrations in the skin adjacent to the healing wounds. Presence of paclitaxel downstream from the PCB treatment site does not impair the wound healing response of preexisting distal cutaneous lesions in healthy swine. Elsevier 2021-03-31 /pmc/articles/PMC8165120/ /pubmed/34095632 http://dx.doi.org/10.1016/j.jacbts.2021.01.012 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preclinical Research
Granada, Juan F.
Ferrone, Marco
Melnick, Gilberto
Crookall, Lesley
Schulz-Jander, Daniel
Tunev, Stefan
Melder, Robert J.
Kaluza, Grzegorz L.
Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine
title Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine
title_full Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine
title_fullStr Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine
title_full_unstemmed Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine
title_short Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine
title_sort downstream paclitaxel released following drug-coated balloon inflation and distal limb wound healing in swine
topic Preclinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165120/
https://www.ncbi.nlm.nih.gov/pubmed/34095632
http://dx.doi.org/10.1016/j.jacbts.2021.01.012
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