Therapy of Pediatric-Onset Multiple Sclerosis: State of the Art, Challenges, and Opportunities

Treatment of pediatric-onset multiple sclerosis (POMS) has been tailored after observational studies and data obtained from clinical trials in adult-onset multiple sclerosis (AOMS) patients. There are an increasing number of new therapeutic agents for AOMS, and many will be formally studied for use...

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Autores principales: Margoni, Monica, Rinaldi, Francesca, Perini, Paola, Gallo, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165183/
https://www.ncbi.nlm.nih.gov/pubmed/34079516
http://dx.doi.org/10.3389/fneur.2021.676095
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author Margoni, Monica
Rinaldi, Francesca
Perini, Paola
Gallo, Paolo
author_facet Margoni, Monica
Rinaldi, Francesca
Perini, Paola
Gallo, Paolo
author_sort Margoni, Monica
collection PubMed
description Treatment of pediatric-onset multiple sclerosis (POMS) has been tailored after observational studies and data obtained from clinical trials in adult-onset multiple sclerosis (AOMS) patients. There are an increasing number of new therapeutic agents for AOMS, and many will be formally studied for use also in POMS. However, there are important efficacy and safety concerns regarding the use of these therapies in children and young adults. This review will discuss the current state of the art of POMS therapy and will focus on the newer therapies (oral and infusion disease-modifying drugs) and on those still currently under investigation.
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spelling pubmed-81651832021-06-01 Therapy of Pediatric-Onset Multiple Sclerosis: State of the Art, Challenges, and Opportunities Margoni, Monica Rinaldi, Francesca Perini, Paola Gallo, Paolo Front Neurol Neurology Treatment of pediatric-onset multiple sclerosis (POMS) has been tailored after observational studies and data obtained from clinical trials in adult-onset multiple sclerosis (AOMS) patients. There are an increasing number of new therapeutic agents for AOMS, and many will be formally studied for use also in POMS. However, there are important efficacy and safety concerns regarding the use of these therapies in children and young adults. This review will discuss the current state of the art of POMS therapy and will focus on the newer therapies (oral and infusion disease-modifying drugs) and on those still currently under investigation. Frontiers Media S.A. 2021-05-17 /pmc/articles/PMC8165183/ /pubmed/34079516 http://dx.doi.org/10.3389/fneur.2021.676095 Text en Copyright © 2021 Margoni, Rinaldi, Perini and Gallo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Margoni, Monica
Rinaldi, Francesca
Perini, Paola
Gallo, Paolo
Therapy of Pediatric-Onset Multiple Sclerosis: State of the Art, Challenges, and Opportunities
title Therapy of Pediatric-Onset Multiple Sclerosis: State of the Art, Challenges, and Opportunities
title_full Therapy of Pediatric-Onset Multiple Sclerosis: State of the Art, Challenges, and Opportunities
title_fullStr Therapy of Pediatric-Onset Multiple Sclerosis: State of the Art, Challenges, and Opportunities
title_full_unstemmed Therapy of Pediatric-Onset Multiple Sclerosis: State of the Art, Challenges, and Opportunities
title_short Therapy of Pediatric-Onset Multiple Sclerosis: State of the Art, Challenges, and Opportunities
title_sort therapy of pediatric-onset multiple sclerosis: state of the art, challenges, and opportunities
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165183/
https://www.ncbi.nlm.nih.gov/pubmed/34079516
http://dx.doi.org/10.3389/fneur.2021.676095
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