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Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou

Objective: Vitamin D deficiency and insufficiency in children are global public health problems. However, few studies have focused on vitamin D status in healthy preschool children, especially in Asia. This study aimed to investigate vitamin D status and host-related factors in healthy preschool chi...

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Autores principales: Chen, Zhaojun, Lv, Xi, Hu, Wensheng, Qian, Xia, Wu, Ting, Zhu, Yunxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165265/
https://www.ncbi.nlm.nih.gov/pubmed/34079788
http://dx.doi.org/10.3389/fpubh.2021.675403
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author Chen, Zhaojun
Lv, Xi
Hu, Wensheng
Qian, Xia
Wu, Ting
Zhu, Yunxia
author_facet Chen, Zhaojun
Lv, Xi
Hu, Wensheng
Qian, Xia
Wu, Ting
Zhu, Yunxia
author_sort Chen, Zhaojun
collection PubMed
description Objective: Vitamin D deficiency and insufficiency in children are global public health problems. However, few studies have focused on vitamin D status in healthy preschool children, especially in Asia. This study aimed to investigate vitamin D status and host-related factors in healthy preschool children in Hangzhou to analyze the impact of low vitamin D levels (<30 ng/mL) on health outcomes (obesity, early childhood caries, and respiratory tract infections). Methods: A total of 1,510 healthy children aged 24–72 months from 15 kindergartens in Hangzhou were included. Data on the children's gender, age, body mass index (BMI), caries, and blood samples available for vitamin D analysis were collected from June to August 2018. A total of 325 children aged 36–48 months took part in a survey on the frequency of respiratory tract infections in the last year. Results: The children's mean 25(OH)D level was 28.01 ± 7.29 ng/mL. A total of 11.4% of the children had vitamin D deficiency, and 52.6% had vitamin D insufficiency. Only 36.0% had vitamin D sufficiency. No significant difference was found by gender or BMI group. However, children in the obesity group had the highest prevalence of vitamin D deficiency and the lowest 25(OH)D levels. A significant negative correlation was found between the 25(OH)D level and child age (r = −0.144, p < 0.001). Regression analysis showed that the children’s 25(OH)D levels decreased by 0.17 ng/mL per month with age. In addition, children with low vitamin D levels might increase the risk of obesity and early childhood caries. Multiple linear regression indicated that the number of caries in children increased by 0.08 per 1-ng/mL decrease in the 25(OH)D level (β = −0.08, p < 0.001). Conclusion: Vitamin D deficiency/insufficiency is a serious problem among healthy preschool children in Hangzhou. Public health policies or interventions should be implemented to ensure that preschool children have adequate vitamin D to reduce the risk of related diseases.
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spelling pubmed-81652652021-06-01 Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou Chen, Zhaojun Lv, Xi Hu, Wensheng Qian, Xia Wu, Ting Zhu, Yunxia Front Public Health Public Health Objective: Vitamin D deficiency and insufficiency in children are global public health problems. However, few studies have focused on vitamin D status in healthy preschool children, especially in Asia. This study aimed to investigate vitamin D status and host-related factors in healthy preschool children in Hangzhou to analyze the impact of low vitamin D levels (<30 ng/mL) on health outcomes (obesity, early childhood caries, and respiratory tract infections). Methods: A total of 1,510 healthy children aged 24–72 months from 15 kindergartens in Hangzhou were included. Data on the children's gender, age, body mass index (BMI), caries, and blood samples available for vitamin D analysis were collected from June to August 2018. A total of 325 children aged 36–48 months took part in a survey on the frequency of respiratory tract infections in the last year. Results: The children's mean 25(OH)D level was 28.01 ± 7.29 ng/mL. A total of 11.4% of the children had vitamin D deficiency, and 52.6% had vitamin D insufficiency. Only 36.0% had vitamin D sufficiency. No significant difference was found by gender or BMI group. However, children in the obesity group had the highest prevalence of vitamin D deficiency and the lowest 25(OH)D levels. A significant negative correlation was found between the 25(OH)D level and child age (r = −0.144, p < 0.001). Regression analysis showed that the children’s 25(OH)D levels decreased by 0.17 ng/mL per month with age. In addition, children with low vitamin D levels might increase the risk of obesity and early childhood caries. Multiple linear regression indicated that the number of caries in children increased by 0.08 per 1-ng/mL decrease in the 25(OH)D level (β = −0.08, p < 0.001). Conclusion: Vitamin D deficiency/insufficiency is a serious problem among healthy preschool children in Hangzhou. Public health policies or interventions should be implemented to ensure that preschool children have adequate vitamin D to reduce the risk of related diseases. Frontiers Media S.A. 2021-05-17 /pmc/articles/PMC8165265/ /pubmed/34079788 http://dx.doi.org/10.3389/fpubh.2021.675403 Text en Copyright © 2021 Chen, Lv, Hu, Qian, Wu and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Chen, Zhaojun
Lv, Xi
Hu, Wensheng
Qian, Xia
Wu, Ting
Zhu, Yunxia
Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou
title Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou
title_full Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou
title_fullStr Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou
title_full_unstemmed Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou
title_short Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou
title_sort vitamin d status and its influence on the health of preschool children in hangzhou
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165265/
https://www.ncbi.nlm.nih.gov/pubmed/34079788
http://dx.doi.org/10.3389/fpubh.2021.675403
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