Airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment in vitro

Airway smooth muscle cells from severe asthma patients with FAO respond to β(2)-agonists and corticosteroids in vitro, and at a level similar to mild asthmatics. Intrinsic dysfunction of these signalling pathways is unlikely to contribute to FAO. https://bit.ly/3muvNsW

Detalles Bibliográficos
Autores principales: Rutting, Sandra, Xenaki, Dia, Reddy, Karosham D., Baraket, Melissa, Chapman, David G., King, Gregory G., Oliver, Brian G., Tonga, Katrina O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Original Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165371/
https://www.ncbi.nlm.nih.gov/pubmed/34084782
http://dx.doi.org/10.1183/23120541.00117-2021
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author Rutting, Sandra
Xenaki, Dia
Reddy, Karosham D.
Baraket, Melissa
Chapman, David G.
King, Gregory G.
Oliver, Brian G.
Tonga, Katrina O.
author_facet Rutting, Sandra
Xenaki, Dia
Reddy, Karosham D.
Baraket, Melissa
Chapman, David G.
King, Gregory G.
Oliver, Brian G.
Tonga, Katrina O.
author_sort Rutting, Sandra
collection PubMed
description Airway smooth muscle cells from severe asthma patients with FAO respond to β(2)-agonists and corticosteroids in vitro, and at a level similar to mild asthmatics. Intrinsic dysfunction of these signalling pathways is unlikely to contribute to FAO. https://bit.ly/3muvNsW
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spelling pubmed-81653712021-06-02 Airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment in vitro Rutting, Sandra Xenaki, Dia Reddy, Karosham D. Baraket, Melissa Chapman, David G. King, Gregory G. Oliver, Brian G. Tonga, Katrina O. ERJ Open Res Original Research Letters Airway smooth muscle cells from severe asthma patients with FAO respond to β(2)-agonists and corticosteroids in vitro, and at a level similar to mild asthmatics. Intrinsic dysfunction of these signalling pathways is unlikely to contribute to FAO. https://bit.ly/3muvNsW European Respiratory Society 2021-05-31 /pmc/articles/PMC8165371/ /pubmed/34084782 http://dx.doi.org/10.1183/23120541.00117-2021 Text en Copyright ©The authors 2021 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Original Research Letters
Rutting, Sandra
Xenaki, Dia
Reddy, Karosham D.
Baraket, Melissa
Chapman, David G.
King, Gregory G.
Oliver, Brian G.
Tonga, Katrina O.
Airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment in vitro
title Airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment in vitro
title_full Airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment in vitro
title_fullStr Airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment in vitro
title_full_unstemmed Airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment in vitro
title_short Airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment in vitro
title_sort airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment in vitro
topic Original Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165371/
https://www.ncbi.nlm.nih.gov/pubmed/34084782
http://dx.doi.org/10.1183/23120541.00117-2021
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