Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques

Cholesterol-25-hydroxylase (CH25H) and its enzymatic product 25-hydroxycholesterol (25HC) exert broadly antiviral activity including inhibiting HIV-1 infection. However, their antiviral immunity and therapeutic efficacy in a nonhuman primate model are unknown. Here, we report that the regimen of 25H...

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Detalles Bibliográficos
Autores principales: Wu, Chunxiu, Zhao, Jin, Li, Ruiting, Feng, Fengling, He, Yizi, Li, Yanjun, Huang, Runhan, Li, Guangye, Yang, Heng, Cheng, Genhong, Chen, Ling, Ma, Feng, Li, Pingchao, Sun, Caijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165512/
https://www.ncbi.nlm.nih.gov/pubmed/34057681
http://dx.doi.org/10.1007/s12250-021-00407-6

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