Cargando…
Maintenance therapy for untreated diffuse large B-cell lymphoma: a systematic review and network meta-analysis
BACKGROUND: Several clinical trials have been conducted to evaluate the role of maintenance therapy in untreated diffuse large B-cell lymphoma (DLBCL) patients with complete response or partial response following standard immunochemotherapy; however, the effect of maintenance therapy remains uncerta...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165531/ https://www.ncbi.nlm.nih.gov/pubmed/34104373 http://dx.doi.org/10.1177/20406207211018894 |
_version_ | 1783701341630103552 |
---|---|
author | Yuan, Ting Zhang, Feng Yao, Qingmin Liu, Yanxia Zhu, Xiaojuan Chen, Peng |
author_facet | Yuan, Ting Zhang, Feng Yao, Qingmin Liu, Yanxia Zhu, Xiaojuan Chen, Peng |
author_sort | Yuan, Ting |
collection | PubMed |
description | BACKGROUND: Several clinical trials have been conducted to evaluate the role of maintenance therapy in untreated diffuse large B-cell lymphoma (DLBCL) patients with complete response or partial response following standard immunochemotherapy; however, the effect of maintenance therapy remains uncertain, and a suitable maintenance strategy has not been determined because of the lack of direct/indirect comparisons. METHODS: We performed a systematic review and Bayesian network meta-analysis (NMA) to analyze and compare the effectiveness of different maintenance regimens in newly diagnosed DLBCL patients. We searched the PubMed Medline, Embase, Web of Science, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials for relevant papers from inception to 18 March 2021. Our study was prospectively registered in the International Prospective Register of Systematic Reviews (CRD42020168864). Data on overall survival (OS) were extracted and the treatments were ranked using the surface under the cumulative ranking (SUCRA) curve. RESULTS: Eight trials and seven treatments involving 3525 patients were analyzed. OS analysis indicated that none of the drugs showed any benefit compared with non-maintenance therapy. Maintenance therapy with lenalidomide (SUCRA 69.3%) was ranked first in terms of OS. CONCLUSION: Based on the OS results observed in this NMA, we do not recommend maintenance therapy in patients with newly diagnosed DLBLC after first-line therapy. |
format | Online Article Text |
id | pubmed-8165531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-81655312021-06-07 Maintenance therapy for untreated diffuse large B-cell lymphoma: a systematic review and network meta-analysis Yuan, Ting Zhang, Feng Yao, Qingmin Liu, Yanxia Zhu, Xiaojuan Chen, Peng Ther Adv Hematol Meta-Analysis BACKGROUND: Several clinical trials have been conducted to evaluate the role of maintenance therapy in untreated diffuse large B-cell lymphoma (DLBCL) patients with complete response or partial response following standard immunochemotherapy; however, the effect of maintenance therapy remains uncertain, and a suitable maintenance strategy has not been determined because of the lack of direct/indirect comparisons. METHODS: We performed a systematic review and Bayesian network meta-analysis (NMA) to analyze and compare the effectiveness of different maintenance regimens in newly diagnosed DLBCL patients. We searched the PubMed Medline, Embase, Web of Science, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials for relevant papers from inception to 18 March 2021. Our study was prospectively registered in the International Prospective Register of Systematic Reviews (CRD42020168864). Data on overall survival (OS) were extracted and the treatments were ranked using the surface under the cumulative ranking (SUCRA) curve. RESULTS: Eight trials and seven treatments involving 3525 patients were analyzed. OS analysis indicated that none of the drugs showed any benefit compared with non-maintenance therapy. Maintenance therapy with lenalidomide (SUCRA 69.3%) was ranked first in terms of OS. CONCLUSION: Based on the OS results observed in this NMA, we do not recommend maintenance therapy in patients with newly diagnosed DLBLC after first-line therapy. SAGE Publications 2021-05-29 /pmc/articles/PMC8165531/ /pubmed/34104373 http://dx.doi.org/10.1177/20406207211018894 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Meta-Analysis Yuan, Ting Zhang, Feng Yao, Qingmin Liu, Yanxia Zhu, Xiaojuan Chen, Peng Maintenance therapy for untreated diffuse large B-cell lymphoma: a systematic review and network meta-analysis |
title | Maintenance therapy for untreated diffuse large B-cell lymphoma: a systematic review and network meta-analysis |
title_full | Maintenance therapy for untreated diffuse large B-cell lymphoma: a systematic review and network meta-analysis |
title_fullStr | Maintenance therapy for untreated diffuse large B-cell lymphoma: a systematic review and network meta-analysis |
title_full_unstemmed | Maintenance therapy for untreated diffuse large B-cell lymphoma: a systematic review and network meta-analysis |
title_short | Maintenance therapy for untreated diffuse large B-cell lymphoma: a systematic review and network meta-analysis |
title_sort | maintenance therapy for untreated diffuse large b-cell lymphoma: a systematic review and network meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165531/ https://www.ncbi.nlm.nih.gov/pubmed/34104373 http://dx.doi.org/10.1177/20406207211018894 |
work_keys_str_mv | AT yuanting maintenancetherapyforuntreateddiffuselargebcelllymphomaasystematicreviewandnetworkmetaanalysis AT zhangfeng maintenancetherapyforuntreateddiffuselargebcelllymphomaasystematicreviewandnetworkmetaanalysis AT yaoqingmin maintenancetherapyforuntreateddiffuselargebcelllymphomaasystematicreviewandnetworkmetaanalysis AT liuyanxia maintenancetherapyforuntreateddiffuselargebcelllymphomaasystematicreviewandnetworkmetaanalysis AT zhuxiaojuan maintenancetherapyforuntreateddiffuselargebcelllymphomaasystematicreviewandnetworkmetaanalysis AT chenpeng maintenancetherapyforuntreateddiffuselargebcelllymphomaasystematicreviewandnetworkmetaanalysis |