Molecular basis for diaryldiamine selectivity and competition with tRNA in a type 2 methionyl-tRNA synthetase from a Gram-negative bacterium

Gram-negative bacteria are responsible for a variety of human, animal, and plant diseases. The spread of multidrug-resistant Gram-negative bacteria poses a challenge to disease control and highlights the need for novel antimicrobials. Owing to their critical role in protein synthesis, aminoacyl-tRNA...

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Detalles Bibliográficos
Autores principales: Mercaldi, Gustavo Fernando, Andrade, Maxuel de Oliveira, Zanella, Jackeline de Lima, Cordeiro, Artur Torres, Benedetti, Celso Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165550/
https://www.ncbi.nlm.nih.gov/pubmed/33857480
http://dx.doi.org/10.1016/j.jbc.2021.100658

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