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Outbreaks in care homes may lead to substantial disease burden if not mitigated

The number of COVID-19 outbreaks reported in UK care homes rose rapidly in early March of 2020. Owing to the increased co-morbidities and therefore worse COVID-19 outcomes for care home residents, it is important that we understand this increase and its future implications. We demonstrate the use of...

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Detalles Bibliográficos
Autores principales: Hall, Ian, Lewkowicz, Hugo, Webb, Luke, House, Thomas, Pellis, Lorenzo, Sedgwick, James, Gent, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165603/
https://www.ncbi.nlm.nih.gov/pubmed/34053256
http://dx.doi.org/10.1098/rstb.2020.0269
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author Hall, Ian
Lewkowicz, Hugo
Webb, Luke
House, Thomas
Pellis, Lorenzo
Sedgwick, James
Gent, Nick
author_facet Hall, Ian
Lewkowicz, Hugo
Webb, Luke
House, Thomas
Pellis, Lorenzo
Sedgwick, James
Gent, Nick
author_sort Hall, Ian
collection PubMed
description The number of COVID-19 outbreaks reported in UK care homes rose rapidly in early March of 2020. Owing to the increased co-morbidities and therefore worse COVID-19 outcomes for care home residents, it is important that we understand this increase and its future implications. We demonstrate the use of an SIS model where each nursing home is an infective unit capable of either being susceptible to an outbreak (S) or in an active outbreak (I). We use a generalized additive model to approximate the trend in growth rate of outbreaks in care homes and find the fit to be improved in a model where the growth rate is proportional to the number of current care home outbreaks compared with a model with a constant growth rate. Using parameters found from the outbreak-dependent growth rate, we predict a 73% prevalence of outbreaks in UK care homes without intervention as a reasonable worst-case planning assumption. This article is part of the theme issue ‘Modelling that shaped the early COVID-19 pandemic response in the UK’.
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spelling pubmed-81656032021-06-03 Outbreaks in care homes may lead to substantial disease burden if not mitigated Hall, Ian Lewkowicz, Hugo Webb, Luke House, Thomas Pellis, Lorenzo Sedgwick, James Gent, Nick Philos Trans R Soc Lond B Biol Sci Articles The number of COVID-19 outbreaks reported in UK care homes rose rapidly in early March of 2020. Owing to the increased co-morbidities and therefore worse COVID-19 outcomes for care home residents, it is important that we understand this increase and its future implications. We demonstrate the use of an SIS model where each nursing home is an infective unit capable of either being susceptible to an outbreak (S) or in an active outbreak (I). We use a generalized additive model to approximate the trend in growth rate of outbreaks in care homes and find the fit to be improved in a model where the growth rate is proportional to the number of current care home outbreaks compared with a model with a constant growth rate. Using parameters found from the outbreak-dependent growth rate, we predict a 73% prevalence of outbreaks in UK care homes without intervention as a reasonable worst-case planning assumption. This article is part of the theme issue ‘Modelling that shaped the early COVID-19 pandemic response in the UK’. The Royal Society 2021-07-19 2021-05-31 /pmc/articles/PMC8165603/ /pubmed/34053256 http://dx.doi.org/10.1098/rstb.2020.0269 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Articles
Hall, Ian
Lewkowicz, Hugo
Webb, Luke
House, Thomas
Pellis, Lorenzo
Sedgwick, James
Gent, Nick
Outbreaks in care homes may lead to substantial disease burden if not mitigated
title Outbreaks in care homes may lead to substantial disease burden if not mitigated
title_full Outbreaks in care homes may lead to substantial disease burden if not mitigated
title_fullStr Outbreaks in care homes may lead to substantial disease burden if not mitigated
title_full_unstemmed Outbreaks in care homes may lead to substantial disease burden if not mitigated
title_short Outbreaks in care homes may lead to substantial disease burden if not mitigated
title_sort outbreaks in care homes may lead to substantial disease burden if not mitigated
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165603/
https://www.ncbi.nlm.nih.gov/pubmed/34053256
http://dx.doi.org/10.1098/rstb.2020.0269
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