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Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2

Adaptor protein 2 (AP2), a heterotetrameric complex comprising AP2α, AP2β2, AP2μ2 and AP2σ2 subunits, is ubiquitously expressed and involved in endocytosis and trafficking of membrane proteins, such as the calcium-sensing receptor (CaSR), a G-protein coupled receptor that signals via Gα(11). Mutatio...

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Detalles Bibliográficos
Autores principales:	Hannan, Fadil M, Stevenson, Mark, Bayliss, Asha L, Stokes, Victoria J, Stewart, Michelle, Kooblall, Kreepa G, Gorvin, Caroline M, Codner, Gemma, Teboul, Lydia, Wells, Sara, Thakker, Rajesh V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165646/ https://www.ncbi.nlm.nih.gov/pubmed/33729479 http://dx.doi.org/10.1093/hmg/ddab076

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