Drug sensitivity profile of minor KRAS mutations in colorectal cancer using mix culture assay: The effect of AMG-510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL-XL

Colorectal cancer with a Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) gene mutation is considered to be resistant to anti-EGFR agents. G12D is the most common KRAS mutation in colorectal cancer, followed by G12V and G13D. According to clinical and basic research data, patients with colorectal...

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Detalles Bibliográficos
Autores principales: Kitazawa, Masato, Miyagawa, Yusuke, Koyama, Makoto, Nakamura, Satoshi, Hondo, Nao, Miyazaki, Satoru, Muranaka, Futoshi, Tokumaru, Shigeo, Yamamoto, Yuta, Ehara, Takehito, Kuroiwa, Masatsugu, Tanaka, Hirokazu, Komatsu, Daisuke, Takeoka, Michiko, Soejima, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165703/
https://www.ncbi.nlm.nih.gov/pubmed/34094546
http://dx.doi.org/10.3892/mco.2021.2310

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