Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran

OBJECTIVE: Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of cagA and v...

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Autores principales: Rasi-Bonab, Farnaz, Jafari-Sales, Abolfazl, Shaverdi, Mohammad Amin, Navidifar, Tahereh, Saki, Morteza, Ghorbani, Atosa, Adekanmbi, Abimbola Olumide, Jafari, Behboud, Naebi, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
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Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165783/
https://www.ncbi.nlm.nih.gov/pubmed/34059110
http://dx.doi.org/10.1186/s13104-021-05633-5
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author Rasi-Bonab, Farnaz
Jafari-Sales, Abolfazl
Shaverdi, Mohammad Amin
Navidifar, Tahereh
Saki, Morteza
Ghorbani, Atosa
Adekanmbi, Abimbola Olumide
Jafari, Behboud
Naebi, Sara
author_facet Rasi-Bonab, Farnaz
Jafari-Sales, Abolfazl
Shaverdi, Mohammad Amin
Navidifar, Tahereh
Saki, Morteza
Ghorbani, Atosa
Adekanmbi, Abimbola Olumide
Jafari, Behboud
Naebi, Sara
author_sort Rasi-Bonab, Farnaz
collection PubMed
description OBJECTIVE: Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of cagA and vacA genes in H. pylori isolates obtained from patients in the clinical centers in Tabriz city, Iran. RESULTS: The culture method detected 100 (45.25%) H. pylori isolates from 221 biopsy samples during 3 years. The results showed that 63% and 81% of the isolates were positive for cagA and vacA genes, respectively. The highest resistance of isolates was seen against metronidazole (79%) and amoxicillin (36%), respectively. Also, the isolates showed the least resistance to tetracycline (8%).
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spelling pubmed-81657832021-06-01 Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran Rasi-Bonab, Farnaz Jafari-Sales, Abolfazl Shaverdi, Mohammad Amin Navidifar, Tahereh Saki, Morteza Ghorbani, Atosa Adekanmbi, Abimbola Olumide Jafari, Behboud Naebi, Sara BMC Res Notes Research Note OBJECTIVE: Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of cagA and vacA genes in H. pylori isolates obtained from patients in the clinical centers in Tabriz city, Iran. RESULTS: The culture method detected 100 (45.25%) H. pylori isolates from 221 biopsy samples during 3 years. The results showed that 63% and 81% of the isolates were positive for cagA and vacA genes, respectively. The highest resistance of isolates was seen against metronidazole (79%) and amoxicillin (36%), respectively. Also, the isolates showed the least resistance to tetracycline (8%). BioMed Central 2021-05-31 /pmc/articles/PMC8165783/ /pubmed/34059110 http://dx.doi.org/10.1186/s13104-021-05633-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Rasi-Bonab, Farnaz
Jafari-Sales, Abolfazl
Shaverdi, Mohammad Amin
Navidifar, Tahereh
Saki, Morteza
Ghorbani, Atosa
Adekanmbi, Abimbola Olumide
Jafari, Behboud
Naebi, Sara
Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
title Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
title_full Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
title_fullStr Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
title_full_unstemmed Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
title_short Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran
title_sort antibiotic resistance pattern and frequency of caga and vaca genes in helicobacter pylori strains isolated from patients in tabriz city, iran
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165783/
https://www.ncbi.nlm.nih.gov/pubmed/34059110
http://dx.doi.org/10.1186/s13104-021-05633-5
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