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Exonic variants undergoing allele-specific selection in cancers

BACKGROUND: Allelic imbalance (AI) in tumors is caused by chromosomal and sub-chromosomal gains and losses. RESULTS: We evaluated AI at 109,086 germline exonic SNP loci in four cancer types, and identified a set of SNPs that demonstrate strong tumor allele specificity in AI events. Further analyses...

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Detalles Bibliográficos
Autores principales:	Li, Qiyuan, Zeng, Yuanyuan, Wang, Janet, Fang, Hongkun, Guo, Jintao, Yu, Liying, Zhong, Taoling, Xu, Chaoqun, Freedman, Matthew, LaFramboise, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166126/ https://www.ncbi.nlm.nih.gov/pubmed/34059054 http://dx.doi.org/10.1186/s12920-021-00984-1

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