Challenges in exploring and manipulating the human skin microbiome

The skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease...

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Detalles Bibliográficos
Autores principales: Boxberger, Manon, Cenizo, Valérie, Cassir, Nadim, La Scola, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166136/
https://www.ncbi.nlm.nih.gov/pubmed/34053468
http://dx.doi.org/10.1186/s40168-021-01062-5
Descripción
Sumario:The skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease and their modulation by intrinsic and extrinsic factors, with a focus on the pathobiological basis of skin aging. We also describe the most recent tools for investigating the skin microbiota composition and microbe-skin relationships and perspectives regarding the challenges of skin microbiome manipulation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40168-021-01062-5.

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