Challenges in exploring and manipulating the human skin microbiome

The skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease...

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Detalles Bibliográficos
Autores principales: Boxberger, Manon, Cenizo, Valérie, Cassir, Nadim, La Scola, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166136/
https://www.ncbi.nlm.nih.gov/pubmed/34053468
http://dx.doi.org/10.1186/s40168-021-01062-5
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author Boxberger, Manon
Cenizo, Valérie
Cassir, Nadim
La Scola, Bernard
author_facet Boxberger, Manon
Cenizo, Valérie
Cassir, Nadim
La Scola, Bernard
author_sort Boxberger, Manon
collection PubMed
description The skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease and their modulation by intrinsic and extrinsic factors, with a focus on the pathobiological basis of skin aging. We also describe the most recent tools for investigating the skin microbiota composition and microbe-skin relationships and perspectives regarding the challenges of skin microbiome manipulation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40168-021-01062-5.
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spelling pubmed-81661362021-06-02 Challenges in exploring and manipulating the human skin microbiome Boxberger, Manon Cenizo, Valérie Cassir, Nadim La Scola, Bernard Microbiome Review The skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease and their modulation by intrinsic and extrinsic factors, with a focus on the pathobiological basis of skin aging. We also describe the most recent tools for investigating the skin microbiota composition and microbe-skin relationships and perspectives regarding the challenges of skin microbiome manipulation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40168-021-01062-5. BioMed Central 2021-05-30 /pmc/articles/PMC8166136/ /pubmed/34053468 http://dx.doi.org/10.1186/s40168-021-01062-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Boxberger, Manon
Cenizo, Valérie
Cassir, Nadim
La Scola, Bernard
Challenges in exploring and manipulating the human skin microbiome
title Challenges in exploring and manipulating the human skin microbiome
title_full Challenges in exploring and manipulating the human skin microbiome
title_fullStr Challenges in exploring and manipulating the human skin microbiome
title_full_unstemmed Challenges in exploring and manipulating the human skin microbiome
title_short Challenges in exploring and manipulating the human skin microbiome
title_sort challenges in exploring and manipulating the human skin microbiome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166136/
https://www.ncbi.nlm.nih.gov/pubmed/34053468
http://dx.doi.org/10.1186/s40168-021-01062-5
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