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Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study
Gastric cancer has the second highest incidence among all the malignancies in China, just below lung cancer. Gastric cancer is likewise one of the main sources of cancer related passings. Gastric cancer therefore remains a huge threat to human health. The primary reason is absence of high sensitivit...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166284/ https://www.ncbi.nlm.nih.gov/pubmed/34079823 http://dx.doi.org/10.3389/fmolb.2021.690665 |
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author | Pu, Yan Wen, Xu Jia, Zhangjun Xie, Yu Luan, Changxing Yu, Youjia Chen, Feng Chen, Peng Li, Ding Sun, Yan Zhao, Jian Lv, Haiqin |
author_facet | Pu, Yan Wen, Xu Jia, Zhangjun Xie, Yu Luan, Changxing Yu, Youjia Chen, Feng Chen, Peng Li, Ding Sun, Yan Zhao, Jian Lv, Haiqin |
author_sort | Pu, Yan |
collection | PubMed |
description | Gastric cancer has the second highest incidence among all the malignancies in China, just below lung cancer. Gastric cancer is likewise one of the main sources of cancer related passings. Gastric cancer therefore remains a huge threat to human health. The primary reason is absence of high sensitivity and specificity for early detection while the pathogenesis of GC is stayed muddled. During the last few decades, a lot of GC related genes have been identified. To find candidate GC related variant in these GC related genes, we conducted this case-control study. 29 tagSNPs located in 7 GC related genes were included. 228 gastric cancer patients and 299 healthy controls were enrolled. Significant differences were found between the genotype frequencies of EFNA1 rs4971066 polymorphism between gastric cancer patients and healthy controls. The result indicated that ephrin-A1 tagSNP rs4971066 GT/TT genotypes was significantly associated with reduced susceptibility of gastric cancer development. |
format | Online Article Text |
id | pubmed-8166284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81662842021-06-01 Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study Pu, Yan Wen, Xu Jia, Zhangjun Xie, Yu Luan, Changxing Yu, Youjia Chen, Feng Chen, Peng Li, Ding Sun, Yan Zhao, Jian Lv, Haiqin Front Mol Biosci Molecular Biosciences Gastric cancer has the second highest incidence among all the malignancies in China, just below lung cancer. Gastric cancer is likewise one of the main sources of cancer related passings. Gastric cancer therefore remains a huge threat to human health. The primary reason is absence of high sensitivity and specificity for early detection while the pathogenesis of GC is stayed muddled. During the last few decades, a lot of GC related genes have been identified. To find candidate GC related variant in these GC related genes, we conducted this case-control study. 29 tagSNPs located in 7 GC related genes were included. 228 gastric cancer patients and 299 healthy controls were enrolled. Significant differences were found between the genotype frequencies of EFNA1 rs4971066 polymorphism between gastric cancer patients and healthy controls. The result indicated that ephrin-A1 tagSNP rs4971066 GT/TT genotypes was significantly associated with reduced susceptibility of gastric cancer development. Frontiers Media S.A. 2021-05-17 /pmc/articles/PMC8166284/ /pubmed/34079823 http://dx.doi.org/10.3389/fmolb.2021.690665 Text en Copyright © 2021 Pu, Wen, Jia, Xie, Luan, Yu, Chen, Chen, Li, Sun, Zhao and Lv. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Pu, Yan Wen, Xu Jia, Zhangjun Xie, Yu Luan, Changxing Yu, Youjia Chen, Feng Chen, Peng Li, Ding Sun, Yan Zhao, Jian Lv, Haiqin Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study |
title | Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study |
title_full | Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study |
title_fullStr | Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study |
title_full_unstemmed | Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study |
title_short | Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study |
title_sort | association between polymorphisms in gastric cancer related genes and risk of gastric cancer: a case-control study |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166284/ https://www.ncbi.nlm.nih.gov/pubmed/34079823 http://dx.doi.org/10.3389/fmolb.2021.690665 |
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