A functional polyvinyl alcohol fibrous membrane loaded with artemisinin and chloroquine phosphate

In order to reduce the infection rate of major respiratory diseases, it is crucial to development of masks with antibacterial functions. This paper describes an electrospun polyvinyl alcohol (PVA) fibrous membranes loaded with antibacterial drugs. The concentration of artemisinin (ART)/chloroquine phosphate (CQP) in PVA solution and the process parameters were investigated. Meanwhile, the physical properties and antibacterial effect, filtration performance, respiratory resistance and the surface wettability of drug membranes were tested and analyzed. The results showed that when the mass concentration of PVA was 9 wt.% and the dosage of ART/CQP was 1.5/10 mg/mL, the fibers had uniform thickness and no beads. The prepared PVA fiber membrane has good hydrophilic, filtration and antibacterial properties, and the inhibition zone to Staphylococcus aureus and Escherichia coli was 7 ± 0.3 mm and 4 ± 0.2 mm, respectively. The development of antibacterial PVA drug loaded fibrous membranes has potential value in the application of medical protective mask materials.