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The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome
OBJECTIVE: This study aimed to identify the predictors and threshold of failure in neonatal acute respiratory distress syndrome. METHODS: Newborns with severe acute respiratory distress syndrome aged 0–28 days and gestational age ≥36 weeks were included in the study if their cases were managed with...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166491/ https://www.ncbi.nlm.nih.gov/pubmed/32822669 http://dx.doi.org/10.1016/j.jped.2020.07.005 |
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author | Wu, Hui Hong, Xiaoyang Qu, Yangming Liu, Zhenqiu Zhao, Zhe Liu, Change Ji, Qiong Wang, Jie Xueli, Quan Jianwei, Sun Cheng, Dongliang Feng, Zhi-Chun Yuan, Shi |
author_facet | Wu, Hui Hong, Xiaoyang Qu, Yangming Liu, Zhenqiu Zhao, Zhe Liu, Change Ji, Qiong Wang, Jie Xueli, Quan Jianwei, Sun Cheng, Dongliang Feng, Zhi-Chun Yuan, Shi |
author_sort | Wu, Hui |
collection | PubMed |
description | OBJECTIVE: This study aimed to identify the predictors and threshold of failure in neonatal acute respiratory distress syndrome. METHODS: Newborns with severe acute respiratory distress syndrome aged 0–28 days and gestational age ≥36 weeks were included in the study if their cases were managed with non-extra corporal membrane oxygenation treatments. Patients were divided into two groups according to whether they died before discharge. Predictors of non-extra corporal membrane oxygenation treatment failure were sought, and the threshold of predictors was calculated. RESULTS: A total of 103 patients were included in the study. A total of 77 (74.8%) survived hospitalization and were discharged, whereas 26 (25.2%) died. Receiver operating characteristic analysis of oxygen index, pH, base excess, and combinations of these indicators demonstrated the advantage of the combination of oxygen index and base excess over the others variables regarding their predictive ability. The area under the curve for the combination of oxygen index and base excess was 0.865. When the cut-off values of oxygen index and base excess were 30.0 and −7.4, respectively, the sensitivity and specificity for predicting death were 77.0% and 84.0%, respectively. The model with base excess added a net reclassification improvement of 0.090 to the model without base excess. CONCLUSION: The combination of oxygen index and base excess can be used as a predictor of outcomes in neonates receiving non-extra corporal membrane oxygenation treatment for acute respiratory distress syndrome. In neonates with acute respiratory distress syndrome, if oxygen index >30 and base excess <−7.4, non-extra corporal membrane oxygenation therapy is likely to lead to death. |
format | Online Article Text |
id | pubmed-8166491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81664912021-06-01 The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome Wu, Hui Hong, Xiaoyang Qu, Yangming Liu, Zhenqiu Zhao, Zhe Liu, Change Ji, Qiong Wang, Jie Xueli, Quan Jianwei, Sun Cheng, Dongliang Feng, Zhi-Chun Yuan, Shi J Pediatr (Rio J) Original Article OBJECTIVE: This study aimed to identify the predictors and threshold of failure in neonatal acute respiratory distress syndrome. METHODS: Newborns with severe acute respiratory distress syndrome aged 0–28 days and gestational age ≥36 weeks were included in the study if their cases were managed with non-extra corporal membrane oxygenation treatments. Patients were divided into two groups according to whether they died before discharge. Predictors of non-extra corporal membrane oxygenation treatment failure were sought, and the threshold of predictors was calculated. RESULTS: A total of 103 patients were included in the study. A total of 77 (74.8%) survived hospitalization and were discharged, whereas 26 (25.2%) died. Receiver operating characteristic analysis of oxygen index, pH, base excess, and combinations of these indicators demonstrated the advantage of the combination of oxygen index and base excess over the others variables regarding their predictive ability. The area under the curve for the combination of oxygen index and base excess was 0.865. When the cut-off values of oxygen index and base excess were 30.0 and −7.4, respectively, the sensitivity and specificity for predicting death were 77.0% and 84.0%, respectively. The model with base excess added a net reclassification improvement of 0.090 to the model without base excess. CONCLUSION: The combination of oxygen index and base excess can be used as a predictor of outcomes in neonates receiving non-extra corporal membrane oxygenation treatment for acute respiratory distress syndrome. In neonates with acute respiratory distress syndrome, if oxygen index >30 and base excess <−7.4, non-extra corporal membrane oxygenation therapy is likely to lead to death. Elsevier 2020-08-19 /pmc/articles/PMC8166491/ /pubmed/32822669 http://dx.doi.org/10.1016/j.jped.2020.07.005 Text en © 2020 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Wu, Hui Hong, Xiaoyang Qu, Yangming Liu, Zhenqiu Zhao, Zhe Liu, Change Ji, Qiong Wang, Jie Xueli, Quan Jianwei, Sun Cheng, Dongliang Feng, Zhi-Chun Yuan, Shi The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome |
title | The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome |
title_full | The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome |
title_fullStr | The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome |
title_full_unstemmed | The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome |
title_short | The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome |
title_sort | value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166491/ https://www.ncbi.nlm.nih.gov/pubmed/32822669 http://dx.doi.org/10.1016/j.jped.2020.07.005 |
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