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The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome

OBJECTIVE: This study aimed to identify the predictors and threshold of failure in neonatal acute respiratory distress syndrome. METHODS: Newborns with severe acute respiratory distress syndrome aged 0–28 days and gestational age ≥36 weeks were included in the study if their cases were managed with...

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Autores principales: Wu, Hui, Hong, Xiaoyang, Qu, Yangming, Liu, Zhenqiu, Zhao, Zhe, Liu, Change, Ji, Qiong, Wang, Jie, Xueli, Quan, Jianwei, Sun, Cheng, Dongliang, Feng, Zhi-Chun, Yuan, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166491/
https://www.ncbi.nlm.nih.gov/pubmed/32822669
http://dx.doi.org/10.1016/j.jped.2020.07.005
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author Wu, Hui
Hong, Xiaoyang
Qu, Yangming
Liu, Zhenqiu
Zhao, Zhe
Liu, Change
Ji, Qiong
Wang, Jie
Xueli, Quan
Jianwei, Sun
Cheng, Dongliang
Feng, Zhi-Chun
Yuan, Shi
author_facet Wu, Hui
Hong, Xiaoyang
Qu, Yangming
Liu, Zhenqiu
Zhao, Zhe
Liu, Change
Ji, Qiong
Wang, Jie
Xueli, Quan
Jianwei, Sun
Cheng, Dongliang
Feng, Zhi-Chun
Yuan, Shi
author_sort Wu, Hui
collection PubMed
description OBJECTIVE: This study aimed to identify the predictors and threshold of failure in neonatal acute respiratory distress syndrome. METHODS: Newborns with severe acute respiratory distress syndrome aged 0–28 days and gestational age ≥36 weeks were included in the study if their cases were managed with non-extra corporal membrane oxygenation treatments. Patients were divided into two groups according to whether they died before discharge. Predictors of non-extra corporal membrane oxygenation treatment failure were sought, and the threshold of predictors was calculated. RESULTS: A total of 103 patients were included in the study. A total of 77 (74.8%) survived hospitalization and were discharged, whereas 26 (25.2%) died. Receiver operating characteristic analysis of oxygen index, pH, base excess, and combinations of these indicators demonstrated the advantage of the combination of oxygen index and base excess over the others variables regarding their predictive ability. The area under the curve for the combination of oxygen index and base excess was 0.865. When the cut-off values of oxygen index and base excess were 30.0 and −7.4, respectively, the sensitivity and specificity for predicting death were 77.0% and 84.0%, respectively. The model with base excess added a net reclassification improvement of 0.090 to the model without base excess. CONCLUSION: The combination of oxygen index and base excess can be used as a predictor of outcomes in neonates receiving non-extra corporal membrane oxygenation treatment for acute respiratory distress syndrome. In neonates with acute respiratory distress syndrome, if oxygen index >30 and base excess <−7.4, non-extra corporal membrane oxygenation therapy is likely to lead to death.
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spelling pubmed-81664912021-06-01 The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome Wu, Hui Hong, Xiaoyang Qu, Yangming Liu, Zhenqiu Zhao, Zhe Liu, Change Ji, Qiong Wang, Jie Xueli, Quan Jianwei, Sun Cheng, Dongliang Feng, Zhi-Chun Yuan, Shi J Pediatr (Rio J) Original Article OBJECTIVE: This study aimed to identify the predictors and threshold of failure in neonatal acute respiratory distress syndrome. METHODS: Newborns with severe acute respiratory distress syndrome aged 0–28 days and gestational age ≥36 weeks were included in the study if their cases were managed with non-extra corporal membrane oxygenation treatments. Patients were divided into two groups according to whether they died before discharge. Predictors of non-extra corporal membrane oxygenation treatment failure were sought, and the threshold of predictors was calculated. RESULTS: A total of 103 patients were included in the study. A total of 77 (74.8%) survived hospitalization and were discharged, whereas 26 (25.2%) died. Receiver operating characteristic analysis of oxygen index, pH, base excess, and combinations of these indicators demonstrated the advantage of the combination of oxygen index and base excess over the others variables regarding their predictive ability. The area under the curve for the combination of oxygen index and base excess was 0.865. When the cut-off values of oxygen index and base excess were 30.0 and −7.4, respectively, the sensitivity and specificity for predicting death were 77.0% and 84.0%, respectively. The model with base excess added a net reclassification improvement of 0.090 to the model without base excess. CONCLUSION: The combination of oxygen index and base excess can be used as a predictor of outcomes in neonates receiving non-extra corporal membrane oxygenation treatment for acute respiratory distress syndrome. In neonates with acute respiratory distress syndrome, if oxygen index >30 and base excess <−7.4, non-extra corporal membrane oxygenation therapy is likely to lead to death. Elsevier 2020-08-19 /pmc/articles/PMC8166491/ /pubmed/32822669 http://dx.doi.org/10.1016/j.jped.2020.07.005 Text en © 2020 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Wu, Hui
Hong, Xiaoyang
Qu, Yangming
Liu, Zhenqiu
Zhao, Zhe
Liu, Change
Ji, Qiong
Wang, Jie
Xueli, Quan
Jianwei, Sun
Cheng, Dongliang
Feng, Zhi-Chun
Yuan, Shi
The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome
title The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome
title_full The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome
title_fullStr The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome
title_full_unstemmed The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome
title_short The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome
title_sort value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166491/
https://www.ncbi.nlm.nih.gov/pubmed/32822669
http://dx.doi.org/10.1016/j.jped.2020.07.005
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