Nasopharyngeal Microbiota in SARS-CoV-2 Positive and Negative Patients

We investigated nasopharyngeal microbial community structure in COVID-19-positive and -negative patients. High-throughput 16S ribosomal RNA gene amplicon sequencing revealed significant microbial community structure differences between COVID-19-positive and -negative patients. This proof-of-concept...

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Detalles Bibliográficos
Autores principales: Engen, Phillip A., Naqib, Ankur, Jennings, Cheryl, Green, Stefan J., Landay, Alan, Keshavarzian, Ali, Voigt, Robin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166531/
https://www.ncbi.nlm.nih.gov/pubmed/34058978
http://dx.doi.org/10.1186/s12575-021-00148-6
Descripción
Sumario:We investigated nasopharyngeal microbial community structure in COVID-19-positive and -negative patients. High-throughput 16S ribosomal RNA gene amplicon sequencing revealed significant microbial community structure differences between COVID-19-positive and -negative patients. This proof-of-concept study demonstrates that: (1) nasopharyngeal microbiome communities can be assessed using collection samples already collected for SARS-CoV-2 testing (viral transport media) and (2) SARS-CoV-2 infection is associated with altered dysbiotic microbial profiles which could be a biomarker for disease progression and prognosis in SARS-CoV-2. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12575-021-00148-6.

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