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A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases
Elderly patients with cardiovascular diseases account for a large proportion of Corona virus Disease 2019(COVID-19)related deaths. COVID-19, as a new coronavirus, mainly targets the patient’s lung triggering a cascade of innate and adaptive immune responses in the host. The principal causes of death...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166579/ https://www.ncbi.nlm.nih.gov/pubmed/34074305 http://dx.doi.org/10.1186/s12979-021-00234-z |
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author | Wang, Yuanyuan Pang, Shu-Chao Yang, Ying |
author_facet | Wang, Yuanyuan Pang, Shu-Chao Yang, Ying |
author_sort | Wang, Yuanyuan |
collection | PubMed |
description | Elderly patients with cardiovascular diseases account for a large proportion of Corona virus Disease 2019(COVID-19)related deaths. COVID-19, as a new coronavirus, mainly targets the patient’s lung triggering a cascade of innate and adaptive immune responses in the host. The principal causes of death among COVID-19 patients, especially elderly subjects with cardiovascular diseases, are acute respiratory distress syndrome(ARDS), multiple organ dysfunction syndrome (MODS), and microvascular thrombosis. All prompted by an excessive uncontrolled systemic inflammatory response. Immunosenescence, characterized by systemic and chronic inflammation as well as innate/adaptive immune imbalance, presents both in the elderly and cardiovascular patients. COVID-19 infection further aggravates the existing inflammatory process and lymphocyte depletion leading to uncontrollable systemic inflammatory responses, which is the primary cause of death. Based on the higher mortality, this study attempts to elucidate the pathophysiological mechanisms of COVID-19 in elderly subjects with cardiovascular diseases as well as the cause of the high mortality result from COVID-19. |
format | Online Article Text |
id | pubmed-8166579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81665792021-06-01 A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases Wang, Yuanyuan Pang, Shu-Chao Yang, Ying Immun Ageing Review Elderly patients with cardiovascular diseases account for a large proportion of Corona virus Disease 2019(COVID-19)related deaths. COVID-19, as a new coronavirus, mainly targets the patient’s lung triggering a cascade of innate and adaptive immune responses in the host. The principal causes of death among COVID-19 patients, especially elderly subjects with cardiovascular diseases, are acute respiratory distress syndrome(ARDS), multiple organ dysfunction syndrome (MODS), and microvascular thrombosis. All prompted by an excessive uncontrolled systemic inflammatory response. Immunosenescence, characterized by systemic and chronic inflammation as well as innate/adaptive immune imbalance, presents both in the elderly and cardiovascular patients. COVID-19 infection further aggravates the existing inflammatory process and lymphocyte depletion leading to uncontrollable systemic inflammatory responses, which is the primary cause of death. Based on the higher mortality, this study attempts to elucidate the pathophysiological mechanisms of COVID-19 in elderly subjects with cardiovascular diseases as well as the cause of the high mortality result from COVID-19. BioMed Central 2021-06-01 /pmc/articles/PMC8166579/ /pubmed/34074305 http://dx.doi.org/10.1186/s12979-021-00234-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Wang, Yuanyuan Pang, Shu-Chao Yang, Ying A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases |
title | A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases |
title_full | A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases |
title_fullStr | A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases |
title_full_unstemmed | A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases |
title_short | A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases |
title_sort | potential association between immunosenescence and high covid-19 related mortality among elderly patients with cardiovascular diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166579/ https://www.ncbi.nlm.nih.gov/pubmed/34074305 http://dx.doi.org/10.1186/s12979-021-00234-z |
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