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Advances in coatings on magnesium alloys for cardiovascular stents – A review

Magnesium (Mg) and its alloys, as potential biodegradable materials, have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility. Nevertheless, the occurrence of thrombosis, inflammation, and restenosis of implanted Mg alloy ste...

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Autores principales: Zhang, Zhao-Qi, Yang, Yong-Xin, Li, Jing-An, Zeng, Rong-Chang, Guan, Shao-Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166647/
https://www.ncbi.nlm.nih.gov/pubmed/34136723
http://dx.doi.org/10.1016/j.bioactmat.2021.04.044
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author Zhang, Zhao-Qi
Yang, Yong-Xin
Li, Jing-An
Zeng, Rong-Chang
Guan, Shao-Kang
author_facet Zhang, Zhao-Qi
Yang, Yong-Xin
Li, Jing-An
Zeng, Rong-Chang
Guan, Shao-Kang
author_sort Zhang, Zhao-Qi
collection PubMed
description Magnesium (Mg) and its alloys, as potential biodegradable materials, have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility. Nevertheless, the occurrence of thrombosis, inflammation, and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical applications. Numerous surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological functionality. This review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade, regarding preparation strategies for metal oxide, metal hydroxide, inorganic nonmetallic, polymer, and their composite coatings; and the performance of these strategies in regulating degradation behavior and biofunction. Potential research direction is also concisely discussed to help guide biological functionalized strategies and inspire further innovations. It is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field.
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spelling pubmed-81666472021-06-15 Advances in coatings on magnesium alloys for cardiovascular stents – A review Zhang, Zhao-Qi Yang, Yong-Xin Li, Jing-An Zeng, Rong-Chang Guan, Shao-Kang Bioact Mater Article Magnesium (Mg) and its alloys, as potential biodegradable materials, have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility. Nevertheless, the occurrence of thrombosis, inflammation, and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical applications. Numerous surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological functionality. This review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade, regarding preparation strategies for metal oxide, metal hydroxide, inorganic nonmetallic, polymer, and their composite coatings; and the performance of these strategies in regulating degradation behavior and biofunction. Potential research direction is also concisely discussed to help guide biological functionalized strategies and inspire further innovations. It is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field. KeAi Publishing 2021-05-23 /pmc/articles/PMC8166647/ /pubmed/34136723 http://dx.doi.org/10.1016/j.bioactmat.2021.04.044 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhang, Zhao-Qi
Yang, Yong-Xin
Li, Jing-An
Zeng, Rong-Chang
Guan, Shao-Kang
Advances in coatings on magnesium alloys for cardiovascular stents – A review
title Advances in coatings on magnesium alloys for cardiovascular stents – A review
title_full Advances in coatings on magnesium alloys for cardiovascular stents – A review
title_fullStr Advances in coatings on magnesium alloys for cardiovascular stents – A review
title_full_unstemmed Advances in coatings on magnesium alloys for cardiovascular stents – A review
title_short Advances in coatings on magnesium alloys for cardiovascular stents – A review
title_sort advances in coatings on magnesium alloys for cardiovascular stents – a review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166647/
https://www.ncbi.nlm.nih.gov/pubmed/34136723
http://dx.doi.org/10.1016/j.bioactmat.2021.04.044
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