ActivinA Induced SMAD1/5 Signaling in an iPSC Derived EC Model of Fibrodysplasia Ossificans Progressiva (FOP) Can Be Rescued by the Drug Candidate Saracatinib

Balanced signal transduction is crucial in tissue patterning, particularly in the vasculature. Heterotopic ossification (HO) is tightly linked to vascularization with increased vessel number in hereditary forms of HO, such as Fibrodysplasia ossificans progressiva (FOP). FOP is caused by mutations in...

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Detalles Bibliográficos
Autores principales: Hildebrandt, Susanne, Kampfrath, Branka, Fischer, Kristin, Hildebrand, Laura, Haupt, Julia, Stachelscheid, Harald, Knaus, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166717/
https://www.ncbi.nlm.nih.gov/pubmed/33410098
http://dx.doi.org/10.1007/s12015-020-10103-9

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