Cargando…
Software-based planning of ultrasound and CT-guided percutaneous radiofrequency ablation in hepatic tumors
OBJECTIVES: Radiofrequency ablation (RFA) can be associated with local recurrences in the treatment of liver tumors. Data obtained at our center for an earlier multinational multicenter trial regarding an in-house developed simulation software were re-evaluated in order to analyze whether the softwa...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166805/ https://www.ncbi.nlm.nih.gov/pubmed/33974224 http://dx.doi.org/10.1007/s11548-021-02394-1 |
_version_ | 1783701574469550080 |
---|---|
author | van Amerongen, M. J. Mariappan, P. Voglreiter, P. Flanagan, R. Jenniskens, S. F. M. Pollari, M. Kolesnik, M. Moche, M. Fütterer, J. J. |
author_facet | van Amerongen, M. J. Mariappan, P. Voglreiter, P. Flanagan, R. Jenniskens, S. F. M. Pollari, M. Kolesnik, M. Moche, M. Fütterer, J. J. |
author_sort | van Amerongen, M. J. |
collection | PubMed |
description | OBJECTIVES: Radiofrequency ablation (RFA) can be associated with local recurrences in the treatment of liver tumors. Data obtained at our center for an earlier multinational multicenter trial regarding an in-house developed simulation software were re-evaluated in order to analyze whether the software was able to predict local recurrences. METHODS: Twenty-seven RFA ablations for either primary or secondary hepatic tumors were included. Colorectal liver metastases were shown in 14 patients and hepatocellular carcinoma in 13 patients. Overlap of the simulated volume and the tumor volume was automatically generated and defined as positive predictive value (PPV) and additionally visually assessed. Local recurrence during follow-up was defined as gold standard. Sensitivity and specificity were calculated using the visual assessment and gold standard. RESULTS: Mean tumor size was 18 mm (95% CI 15–21 mm). Local recurrence occurred in 5 patients. The PPV of the simulation showed a mean of 0.89 (0.84–0.93 95% CI). After visual assessment, 9 incomplete ablations were observed, of which 4 true positives and 5 false positives for the detection of an incomplete ablation. The sensitivity and specificity were, respectively, 80% and 77% with a correct prediction in 78% of cases. No significant correlation was found between size of the tumor and PPV (Pearson Correlation 0.10; p = 0.62) or between PPV and recurrence rates (Pearson Correlation 0.28; p = 0.16). CONCLUSIONS: The simulation software shows promise in estimating the completeness of liver RFA treatment and predicting local recurrence rates, but could not be performed real-time. Future improvements in the field of registration could improve results and provide a possibility for real-time implementation. |
format | Online Article Text |
id | pubmed-8166805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-81668052021-06-03 Software-based planning of ultrasound and CT-guided percutaneous radiofrequency ablation in hepatic tumors van Amerongen, M. J. Mariappan, P. Voglreiter, P. Flanagan, R. Jenniskens, S. F. M. Pollari, M. Kolesnik, M. Moche, M. Fütterer, J. J. Int J Comput Assist Radiol Surg Original Article OBJECTIVES: Radiofrequency ablation (RFA) can be associated with local recurrences in the treatment of liver tumors. Data obtained at our center for an earlier multinational multicenter trial regarding an in-house developed simulation software were re-evaluated in order to analyze whether the software was able to predict local recurrences. METHODS: Twenty-seven RFA ablations for either primary or secondary hepatic tumors were included. Colorectal liver metastases were shown in 14 patients and hepatocellular carcinoma in 13 patients. Overlap of the simulated volume and the tumor volume was automatically generated and defined as positive predictive value (PPV) and additionally visually assessed. Local recurrence during follow-up was defined as gold standard. Sensitivity and specificity were calculated using the visual assessment and gold standard. RESULTS: Mean tumor size was 18 mm (95% CI 15–21 mm). Local recurrence occurred in 5 patients. The PPV of the simulation showed a mean of 0.89 (0.84–0.93 95% CI). After visual assessment, 9 incomplete ablations were observed, of which 4 true positives and 5 false positives for the detection of an incomplete ablation. The sensitivity and specificity were, respectively, 80% and 77% with a correct prediction in 78% of cases. No significant correlation was found between size of the tumor and PPV (Pearson Correlation 0.10; p = 0.62) or between PPV and recurrence rates (Pearson Correlation 0.28; p = 0.16). CONCLUSIONS: The simulation software shows promise in estimating the completeness of liver RFA treatment and predicting local recurrence rates, but could not be performed real-time. Future improvements in the field of registration could improve results and provide a possibility for real-time implementation. Springer International Publishing 2021-05-11 2021 /pmc/articles/PMC8166805/ /pubmed/33974224 http://dx.doi.org/10.1007/s11548-021-02394-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article van Amerongen, M. J. Mariappan, P. Voglreiter, P. Flanagan, R. Jenniskens, S. F. M. Pollari, M. Kolesnik, M. Moche, M. Fütterer, J. J. Software-based planning of ultrasound and CT-guided percutaneous radiofrequency ablation in hepatic tumors |
title | Software-based planning of ultrasound and CT-guided percutaneous radiofrequency ablation in hepatic tumors |
title_full | Software-based planning of ultrasound and CT-guided percutaneous radiofrequency ablation in hepatic tumors |
title_fullStr | Software-based planning of ultrasound and CT-guided percutaneous radiofrequency ablation in hepatic tumors |
title_full_unstemmed | Software-based planning of ultrasound and CT-guided percutaneous radiofrequency ablation in hepatic tumors |
title_short | Software-based planning of ultrasound and CT-guided percutaneous radiofrequency ablation in hepatic tumors |
title_sort | software-based planning of ultrasound and ct-guided percutaneous radiofrequency ablation in hepatic tumors |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166805/ https://www.ncbi.nlm.nih.gov/pubmed/33974224 http://dx.doi.org/10.1007/s11548-021-02394-1 |
work_keys_str_mv | AT vanamerongenmj softwarebasedplanningofultrasoundandctguidedpercutaneousradiofrequencyablationinhepatictumors AT mariappanp softwarebasedplanningofultrasoundandctguidedpercutaneousradiofrequencyablationinhepatictumors AT voglreiterp softwarebasedplanningofultrasoundandctguidedpercutaneousradiofrequencyablationinhepatictumors AT flanaganr softwarebasedplanningofultrasoundandctguidedpercutaneousradiofrequencyablationinhepatictumors AT jenniskenssfm softwarebasedplanningofultrasoundandctguidedpercutaneousradiofrequencyablationinhepatictumors AT pollarim softwarebasedplanningofultrasoundandctguidedpercutaneousradiofrequencyablationinhepatictumors AT kolesnikm softwarebasedplanningofultrasoundandctguidedpercutaneousradiofrequencyablationinhepatictumors AT mochem softwarebasedplanningofultrasoundandctguidedpercutaneousradiofrequencyablationinhepatictumors AT futtererjj softwarebasedplanningofultrasoundandctguidedpercutaneousradiofrequencyablationinhepatictumors |