Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases

Excessive release of neutrophil extracellular traps (NETs) is associated with disease severity and contributes to tissue injury, followed by severe organ damage. Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models, indicating that NETs are p...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Chirivi, Renato G. S., van Rosmalen, Jos W. G., van der Linden, Maarten, Euler, Maximilien, Schmets, Gonny, Bogatkevich, Galina, Kambas, Konstantinos, Hahn, Jonas, Braster, Quinte, Soehnlein, Oliver, Hoffmann, Markus H., Es, Helmuth H. G. van, Raats, Jos M. H.
Format: Online Artikel Text
Sprache:English
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Article
Online Zugang:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166830/
https://www.ncbi.nlm.nih.gov/pubmed/32203195
http://dx.doi.org/10.1038/s41423-020-0381-3

Online

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166830/
https://www.ncbi.nlm.nih.gov/pubmed/32203195
http://dx.doi.org/10.1038/s41423-020-0381-3

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