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Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases
Excessive release of neutrophil extracellular traps (NETs) is associated with disease severity and contributes to tissue injury, followed by severe organ damage. Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models, indicating that NETs are p...
Auteurs principaux: | , , , , , , , , , , , , |
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Format: | Online Article Texte |
Langue: | English |
Publié: |
Nature Publishing Group UK
2020
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Sujets: | |
Accès en ligne: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166830/ https://www.ncbi.nlm.nih.gov/pubmed/32203195 http://dx.doi.org/10.1038/s41423-020-0381-3 |