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The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress
To survive proteotoxic stress, cancer cells activate the proteotoxic-stress response pathway, which is controlled by the transcription factor heat shock factor 1 (HSF1). This pathway supports cancer initiation, cancer progression and chemoresistance and thus is an attractive therapeutic target. As d...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166837/ https://www.ncbi.nlm.nih.gov/pubmed/33268814 http://dx.doi.org/10.1038/s41418-020-00686-8 |