Streamlined human antibody generation and optimization by exploiting designed immunoglobulin loci in a B cell line

Monoclonal antibodies (mAbs) are widely utilized as therapeutic drugs for various diseases, such as cancer, autoimmune diseases, and infectious diseases. Using the avian-derived B cell line DT40, we previously developed an antibody display technology, namely, the ADLib system, which rapidly generate...

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Detalles Bibliográficos
Autores principales: Seo, Hidetaka, Masuda, Hitomi, Asagoshi, Kenjiro, Uchiki, Tomoaki, Kawata, Shigehisa, Sasaki, Goh, Yabuki, Takashi, Miyai, Shunsuke, Takahashi, Naoki, Hashimoto, Shu-ichi, Sawada, Atsushi, Takaiwa, Aki, Koyama, Chika, Tamai, Kanako, Kurosawa, Kohei, Lin, Ke-Yi, Ohta, Kunihiro, Nakazaki, Yukoh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166883/
https://www.ncbi.nlm.nih.gov/pubmed/32457406
http://dx.doi.org/10.1038/s41423-020-0440-9

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