Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses

His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whe...

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Detalles Bibliográficos
Autores principales: Adams, Ryan A., Fernandes-Cerqueira, Cátia, Notarnicola, Antonella, Mertsching, Elisabeth, Xu, Zhiwen, Lo, Wing-Sze, Ogilvie, Kathleen, Chiang, Kyle P., Ampudia, Jeanette, Rosengren, Sanna, Cubitt, Andrea, King, David J., Mendlein, John D., Yang, Xiang-Lei, Nangle, Leslie A., Lundberg, Ingrid E., Jakobsson, Per-Johan, Schimmel, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166958/
https://www.ncbi.nlm.nih.gov/pubmed/31797905
http://dx.doi.org/10.1038/s41423-019-0331-0

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