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Extracellular Vesicles for the Treatment of Radiation Injuries
Normal tissue injury from accidental or therapeutic exposure to high-dose radiation can cause severe acute and delayed toxicities, which result in mortality and chronic morbidity. Exposure to single high-dose radiation leads to a multi-organ failure, known as acute radiation syndrome, which is cause...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167064/ https://www.ncbi.nlm.nih.gov/pubmed/34084138 http://dx.doi.org/10.3389/fphar.2021.662437 |
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author | Nanduri, Lalitha Sarad Yamini Duddempudi, Phaneendra K. Yang, Weng-Lang Tamarat, Radia Guha, Chandan |
author_facet | Nanduri, Lalitha Sarad Yamini Duddempudi, Phaneendra K. Yang, Weng-Lang Tamarat, Radia Guha, Chandan |
author_sort | Nanduri, Lalitha Sarad Yamini |
collection | PubMed |
description | Normal tissue injury from accidental or therapeutic exposure to high-dose radiation can cause severe acute and delayed toxicities, which result in mortality and chronic morbidity. Exposure to single high-dose radiation leads to a multi-organ failure, known as acute radiation syndrome, which is caused by radiation-induced oxidative stress and DNA damage to tissue stem cells. The radiation exposure results in acute cell loss, cell cycle arrest, senescence, and early damage to bone marrow and intestine with high mortality from sepsis. There is an urgent need for developing medical countermeasures against radiation injury for normal tissue toxicity. In this review, we discuss the potential of applying secretory extracellular vesicles derived from mesenchymal stromal/stem cells, endothelial cells, and macrophages for promoting repair and regeneration of organs after radiation injury. |
format | Online Article Text |
id | pubmed-8167064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81670642021-06-02 Extracellular Vesicles for the Treatment of Radiation Injuries Nanduri, Lalitha Sarad Yamini Duddempudi, Phaneendra K. Yang, Weng-Lang Tamarat, Radia Guha, Chandan Front Pharmacol Pharmacology Normal tissue injury from accidental or therapeutic exposure to high-dose radiation can cause severe acute and delayed toxicities, which result in mortality and chronic morbidity. Exposure to single high-dose radiation leads to a multi-organ failure, known as acute radiation syndrome, which is caused by radiation-induced oxidative stress and DNA damage to tissue stem cells. The radiation exposure results in acute cell loss, cell cycle arrest, senescence, and early damage to bone marrow and intestine with high mortality from sepsis. There is an urgent need for developing medical countermeasures against radiation injury for normal tissue toxicity. In this review, we discuss the potential of applying secretory extracellular vesicles derived from mesenchymal stromal/stem cells, endothelial cells, and macrophages for promoting repair and regeneration of organs after radiation injury. Frontiers Media S.A. 2021-05-18 /pmc/articles/PMC8167064/ /pubmed/34084138 http://dx.doi.org/10.3389/fphar.2021.662437 Text en Copyright © 2021 Nanduri, Duddempudi, Yang, Tamarat and Guha. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Nanduri, Lalitha Sarad Yamini Duddempudi, Phaneendra K. Yang, Weng-Lang Tamarat, Radia Guha, Chandan Extracellular Vesicles for the Treatment of Radiation Injuries |
title | Extracellular Vesicles for the Treatment of Radiation Injuries |
title_full | Extracellular Vesicles for the Treatment of Radiation Injuries |
title_fullStr | Extracellular Vesicles for the Treatment of Radiation Injuries |
title_full_unstemmed | Extracellular Vesicles for the Treatment of Radiation Injuries |
title_short | Extracellular Vesicles for the Treatment of Radiation Injuries |
title_sort | extracellular vesicles for the treatment of radiation injuries |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167064/ https://www.ncbi.nlm.nih.gov/pubmed/34084138 http://dx.doi.org/10.3389/fphar.2021.662437 |
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