Development of selective bispecific Wnt mimetics for bone loss and repair

The Wnt signaling pathway is intricately connected with bone mass regulation in humans and rodent models. We designed an antibody-based platform that generates potent and selective Wnt mimetics. Using this platform, we engineer bi-specific Wnt mimetics that target Frizzled and low-density lipoprotei...

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Detalles Bibliográficos
Autores principales: Fowler, Tristan W., Mitchell, Troy L., Janda, Claudia Y., Xie, Liqin, Tu, Shengjiang, Chen, Hui, Zhang, Haili, Ye, Jingjing, Ouyang, Brian, Yuan, Tom Z., Lee, Sung-Jin, Newman, Maureen, Tripuraneni, Nikita, Rego, Erica S., Mutha, Devin, Dilip, Archana, Vuppalapaty, Meghah, Baribault, Helene, Yeh, Wen-Chen, Li, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167098/
https://www.ncbi.nlm.nih.gov/pubmed/34059688
http://dx.doi.org/10.1038/s41467-021-23374-8

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