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Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients
Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167112/ https://www.ncbi.nlm.nih.gov/pubmed/33262469 http://dx.doi.org/10.1038/s41418-020-00684-w |
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| author | Picard, Marion Yonekura, Satoru Slowicka, Karolina Petta, Ioanna Rauber, Conrad Routy, Bertrand Richard, Corentin Iebba, Valerio Tidjani Alou, Maryam Becharef, Sonia Ly, Pierre Pizzato, Eugenie Lehmann, Christian H. K. Amon, Lukas Klein, Christophe Opolon, Paule Gomperts Boneca, Ivo Scoazec, Jean-Yves Hollebecque, Antoine Malka, David Ghiringhelli, François Dudziak, Diana Berx, Geert Vereecke, Lars van Loo, Geert Kroemer, Guido Zitvogel, Laurence Roberti, Maria Paula |
| author_facet | Picard, Marion Yonekura, Satoru Slowicka, Karolina Petta, Ioanna Rauber, Conrad Routy, Bertrand Richard, Corentin Iebba, Valerio Tidjani Alou, Maryam Becharef, Sonia Ly, Pierre Pizzato, Eugenie Lehmann, Christian H. K. Amon, Lukas Klein, Christophe Opolon, Paule Gomperts Boneca, Ivo Scoazec, Jean-Yves Hollebecque, Antoine Malka, David Ghiringhelli, François Dudziak, Diana Berx, Geert Vereecke, Lars van Loo, Geert Kroemer, Guido Zitvogel, Laurence Roberti, Maria Paula |
| author_sort | Picard, Marion |
| collection | PubMed |
| description | Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum–tumor axis, influencing clinical outcome. |
| format | Online Article Text |
| id | pubmed-8167112 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-81671122021-06-07 Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients Picard, Marion Yonekura, Satoru Slowicka, Karolina Petta, Ioanna Rauber, Conrad Routy, Bertrand Richard, Corentin Iebba, Valerio Tidjani Alou, Maryam Becharef, Sonia Ly, Pierre Pizzato, Eugenie Lehmann, Christian H. K. Amon, Lukas Klein, Christophe Opolon, Paule Gomperts Boneca, Ivo Scoazec, Jean-Yves Hollebecque, Antoine Malka, David Ghiringhelli, François Dudziak, Diana Berx, Geert Vereecke, Lars van Loo, Geert Kroemer, Guido Zitvogel, Laurence Roberti, Maria Paula Cell Death Differ Article Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum–tumor axis, influencing clinical outcome. Nature Publishing Group UK 2020-12-01 2021-05 /pmc/articles/PMC8167112/ /pubmed/33262469 http://dx.doi.org/10.1038/s41418-020-00684-w Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Picard, Marion Yonekura, Satoru Slowicka, Karolina Petta, Ioanna Rauber, Conrad Routy, Bertrand Richard, Corentin Iebba, Valerio Tidjani Alou, Maryam Becharef, Sonia Ly, Pierre Pizzato, Eugenie Lehmann, Christian H. K. Amon, Lukas Klein, Christophe Opolon, Paule Gomperts Boneca, Ivo Scoazec, Jean-Yves Hollebecque, Antoine Malka, David Ghiringhelli, François Dudziak, Diana Berx, Geert Vereecke, Lars van Loo, Geert Kroemer, Guido Zitvogel, Laurence Roberti, Maria Paula Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients |
| title | Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients |
| title_full | Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients |
| title_fullStr | Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients |
| title_full_unstemmed | Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients |
| title_short | Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients |
| title_sort | ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167112/ https://www.ncbi.nlm.nih.gov/pubmed/33262469 http://dx.doi.org/10.1038/s41418-020-00684-w |
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