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Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy
Multiple sclerosis (MS) is a leading cause of chronic neurological disability in young to middle-aged adults, affecting ~2.5 million people worldwide. Currently, most therapeutics for MS are systemic immunosuppressive or immunomodulatory drugs, but these drugs are unable to halt or reverse the disea...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167140/ https://www.ncbi.nlm.nih.gov/pubmed/33958746 http://dx.doi.org/10.1038/s41423-020-00618-z |
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author | Mansilla, M. J. Presas-Rodríguez, S. Teniente-Serra, A. González-Larreategui, I. Quirant-Sánchez, B. Fondelli, F. Djedovic, N. Iwaszkiewicz-Grześ, D. Chwojnicki, K. Miljković, Đ. Trzonkowski, P. Ramo-Tello, C. Martínez-Cáceres, E. M. |
author_facet | Mansilla, M. J. Presas-Rodríguez, S. Teniente-Serra, A. González-Larreategui, I. Quirant-Sánchez, B. Fondelli, F. Djedovic, N. Iwaszkiewicz-Grześ, D. Chwojnicki, K. Miljković, Đ. Trzonkowski, P. Ramo-Tello, C. Martínez-Cáceres, E. M. |
author_sort | Mansilla, M. J. |
collection | PubMed |
description | Multiple sclerosis (MS) is a leading cause of chronic neurological disability in young to middle-aged adults, affecting ~2.5 million people worldwide. Currently, most therapeutics for MS are systemic immunosuppressive or immunomodulatory drugs, but these drugs are unable to halt or reverse the disease and have the potential to cause serious adverse events. Hence, there is an urgent need for the development of next-generation treatments that, alone or in combination, stop the undesired autoimmune response and contribute to the restoration of homeostasis. This review analyzes current MS treatments as well as different cell-based therapies that have been proposed to restore homeostasis in MS patients (tolerogenic dendritic cells, regulatory T cells, mesenchymal stem cells, and vaccination with T cells). Data collected from preclinical studies performed in the experimental autoimmune encephalomyelitis (EAE) model of MS in animals, in vitro cultures of cells from MS patients and the initial results of phase I/II clinical trials are analyzed to better understand which parameters are relevant for obtaining an efficient cell-based therapy for MS. |
format | Online Article Text |
id | pubmed-8167140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81671402021-06-07 Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy Mansilla, M. J. Presas-Rodríguez, S. Teniente-Serra, A. González-Larreategui, I. Quirant-Sánchez, B. Fondelli, F. Djedovic, N. Iwaszkiewicz-Grześ, D. Chwojnicki, K. Miljković, Đ. Trzonkowski, P. Ramo-Tello, C. Martínez-Cáceres, E. M. Cell Mol Immunol Review Article Multiple sclerosis (MS) is a leading cause of chronic neurological disability in young to middle-aged adults, affecting ~2.5 million people worldwide. Currently, most therapeutics for MS are systemic immunosuppressive or immunomodulatory drugs, but these drugs are unable to halt or reverse the disease and have the potential to cause serious adverse events. Hence, there is an urgent need for the development of next-generation treatments that, alone or in combination, stop the undesired autoimmune response and contribute to the restoration of homeostasis. This review analyzes current MS treatments as well as different cell-based therapies that have been proposed to restore homeostasis in MS patients (tolerogenic dendritic cells, regulatory T cells, mesenchymal stem cells, and vaccination with T cells). Data collected from preclinical studies performed in the experimental autoimmune encephalomyelitis (EAE) model of MS in animals, in vitro cultures of cells from MS patients and the initial results of phase I/II clinical trials are analyzed to better understand which parameters are relevant for obtaining an efficient cell-based therapy for MS. Nature Publishing Group UK 2021-05-06 2021-06 /pmc/articles/PMC8167140/ /pubmed/33958746 http://dx.doi.org/10.1038/s41423-020-00618-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Mansilla, M. J. Presas-Rodríguez, S. Teniente-Serra, A. González-Larreategui, I. Quirant-Sánchez, B. Fondelli, F. Djedovic, N. Iwaszkiewicz-Grześ, D. Chwojnicki, K. Miljković, Đ. Trzonkowski, P. Ramo-Tello, C. Martínez-Cáceres, E. M. Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy |
title | Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy |
title_full | Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy |
title_fullStr | Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy |
title_full_unstemmed | Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy |
title_short | Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy |
title_sort | paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167140/ https://www.ncbi.nlm.nih.gov/pubmed/33958746 http://dx.doi.org/10.1038/s41423-020-00618-z |
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