Upregulation of endogenous TRAIL-elicited apoptosis is essential for metformin-mediated antitumor activity against TNBC and NSCLC

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) shows promising antitumor activity in preclinical studies. However, the efficacy of recombinant TRAIL in clinical trials is compromised by its short serum half-life and low in vivo stability. Induction of endogenous TRAIL may overcome t...

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Detalles Bibliográficos
Autores principales: Liu, Shuang, Polsdofer, Erik V., Zhou, Lukun, Ruan, Sanbao, Lyu, Hui, Hou, Defu, Liu, Hao, Thor, Ann D., He, Zhimin, Liu, Bolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167201/
https://www.ncbi.nlm.nih.gov/pubmed/34141868
http://dx.doi.org/10.1016/j.omto.2021.04.012

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