Structural Investigations of Human A2M Identify a Hollow Native Conformation That Underlies Its Distinctive Protease-Trapping Mechanism

Human α(2)-macroglobulin (A2M) is the most characterized protease inhibitor in the alpha-macroglobulin (αM) superfamily, but the structure of its native conformation has not been determined. Here, we combined negative stain electron microscopy (EM), small-angle X-ray scattering (SAXS), and cross-lin...

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Detalles Bibliográficos
Autores principales: Harwood, Seandean Lykke, Lyngsø, Jeppe, Zarantonello, Alessandra, Kjøge, Katarzyna, Nielsen, Peter Kresten, Andersen, Gregers Rom, Pedersen, Jan Skov, Enghild, Jan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167298/
https://www.ncbi.nlm.nih.gov/pubmed/33964423
http://dx.doi.org/10.1016/j.mcpro.2021.100090

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