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Laboratory tests for the detection of SARS-CoV-2 infection: basic principles and examples

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has circulated throughout the world causing the worst pandemic since 1918. All efforts have been marshalled towards testing different treatment approaches, obtaining clinical and epidemiological information, developing suitable diagnostic...

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Autor principal: Alkharsah, Khaled R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: German Medical Science GMS Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167375/
https://www.ncbi.nlm.nih.gov/pubmed/34108851
http://dx.doi.org/10.3205/000293
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author Alkharsah, Khaled R.
author_facet Alkharsah, Khaled R.
author_sort Alkharsah, Khaled R.
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description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has circulated throughout the world causing the worst pandemic since 1918. All efforts have been marshalled towards testing different treatment approaches, obtaining clinical and epidemiological information, developing suitable diagnostic tests, and developing new vaccines. New ribonucleic acid (RNA)-based and viral vector-based vaccines have been developed and licensed under emergency use in many countries; however, there is a huge demand for vaccines, and it will take some time before a sufficient number of people are vaccinated to stop the circulation of the virus. Therefore, the proper diagnosis and identification of infected individuals are crucial for the isolation and treatment of these patients and tracing of their contacts. Many diagnostic tests and diag-nostic kits have been developed in a relatively short time. This review summarizes the principles of the available laboratory assays that are in use for the detection of SARS-CoV-2 RNA, antigens, or antibodies.
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spelling pubmed-81673752021-06-08 Laboratory tests for the detection of SARS-CoV-2 infection: basic principles and examples Alkharsah, Khaled R. Ger Med Sci Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has circulated throughout the world causing the worst pandemic since 1918. All efforts have been marshalled towards testing different treatment approaches, obtaining clinical and epidemiological information, developing suitable diagnostic tests, and developing new vaccines. New ribonucleic acid (RNA)-based and viral vector-based vaccines have been developed and licensed under emergency use in many countries; however, there is a huge demand for vaccines, and it will take some time before a sufficient number of people are vaccinated to stop the circulation of the virus. Therefore, the proper diagnosis and identification of infected individuals are crucial for the isolation and treatment of these patients and tracing of their contacts. Many diagnostic tests and diag-nostic kits have been developed in a relatively short time. This review summarizes the principles of the available laboratory assays that are in use for the detection of SARS-CoV-2 RNA, antigens, or antibodies. German Medical Science GMS Publishing House 2021-05-27 /pmc/articles/PMC8167375/ /pubmed/34108851 http://dx.doi.org/10.3205/000293 Text en Copyright © 2021 Alkharsah https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Alkharsah, Khaled R.
Laboratory tests for the detection of SARS-CoV-2 infection: basic principles and examples
title Laboratory tests for the detection of SARS-CoV-2 infection: basic principles and examples
title_full Laboratory tests for the detection of SARS-CoV-2 infection: basic principles and examples
title_fullStr Laboratory tests for the detection of SARS-CoV-2 infection: basic principles and examples
title_full_unstemmed Laboratory tests for the detection of SARS-CoV-2 infection: basic principles and examples
title_short Laboratory tests for the detection of SARS-CoV-2 infection: basic principles and examples
title_sort laboratory tests for the detection of sars-cov-2 infection: basic principles and examples
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167375/
https://www.ncbi.nlm.nih.gov/pubmed/34108851
http://dx.doi.org/10.3205/000293
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