Antibody Responses One Year after Mild SARS-CoV-2 Infection

Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) i...

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Autores principales: Choe, Pyoeng Gyun, Kim, Kye-Hyung, Kang, Chang Kyung, Suh, Hyeon Jeong, Kang, EunKyo, Lee, Sun Young, Kim, Nam Joong, Yi, Jongyoun, Park, Wan Beom, Oh, Myoung-don
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167408/
https://www.ncbi.nlm.nih.gov/pubmed/34060263
http://dx.doi.org/10.3346/jkms.2021.36.e157
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author Choe, Pyoeng Gyun
Kim, Kye-Hyung
Kang, Chang Kyung
Suh, Hyeon Jeong
Kang, EunKyo
Lee, Sun Young
Kim, Nam Joong
Yi, Jongyoun
Park, Wan Beom
Oh, Myoung-don
author_facet Choe, Pyoeng Gyun
Kim, Kye-Hyung
Kang, Chang Kyung
Suh, Hyeon Jeong
Kang, EunKyo
Lee, Sun Young
Kim, Nam Joong
Yi, Jongyoun
Park, Wan Beom
Oh, Myoung-don
author_sort Choe, Pyoeng Gyun
collection PubMed
description Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, using three commercial immunoassays and a surrogate virus neutralization test (sVNT) kit. Anti-N pan-immunoglobulin (Ig), anti-S IgG, and anti-S1 IgG were detected in 43 (82.7%), 44 (84.6%), and 30 (57.7%), respectively. In 49 (94.2%), the antibody could be detected by either anti-N pan-Ig or anti-S IgG assay. In the sVNT, 30 (57.7%) had positive neutralizing activity. Despite waning immunity, SARS-CoV-2 antibodies can be detected up to one year after infection, even in mild COVID-19 patients.
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spelling pubmed-81674082021-06-04 Antibody Responses One Year after Mild SARS-CoV-2 Infection Choe, Pyoeng Gyun Kim, Kye-Hyung Kang, Chang Kyung Suh, Hyeon Jeong Kang, EunKyo Lee, Sun Young Kim, Nam Joong Yi, Jongyoun Park, Wan Beom Oh, Myoung-don J Korean Med Sci Brief Communication Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, using three commercial immunoassays and a surrogate virus neutralization test (sVNT) kit. Anti-N pan-immunoglobulin (Ig), anti-S IgG, and anti-S1 IgG were detected in 43 (82.7%), 44 (84.6%), and 30 (57.7%), respectively. In 49 (94.2%), the antibody could be detected by either anti-N pan-Ig or anti-S IgG assay. In the sVNT, 30 (57.7%) had positive neutralizing activity. Despite waning immunity, SARS-CoV-2 antibodies can be detected up to one year after infection, even in mild COVID-19 patients. The Korean Academy of Medical Sciences 2021-05-21 /pmc/articles/PMC8167408/ /pubmed/34060263 http://dx.doi.org/10.3346/jkms.2021.36.e157 Text en © 2021 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Choe, Pyoeng Gyun
Kim, Kye-Hyung
Kang, Chang Kyung
Suh, Hyeon Jeong
Kang, EunKyo
Lee, Sun Young
Kim, Nam Joong
Yi, Jongyoun
Park, Wan Beom
Oh, Myoung-don
Antibody Responses One Year after Mild SARS-CoV-2 Infection
title Antibody Responses One Year after Mild SARS-CoV-2 Infection
title_full Antibody Responses One Year after Mild SARS-CoV-2 Infection
title_fullStr Antibody Responses One Year after Mild SARS-CoV-2 Infection
title_full_unstemmed Antibody Responses One Year after Mild SARS-CoV-2 Infection
title_short Antibody Responses One Year after Mild SARS-CoV-2 Infection
title_sort antibody responses one year after mild sars-cov-2 infection
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167408/
https://www.ncbi.nlm.nih.gov/pubmed/34060263
http://dx.doi.org/10.3346/jkms.2021.36.e157
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