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Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep
BACKGROUND AND AIM: Many metabolic and immunological changes occur during the transition period. Innate immunity plays an important role against to infections and natural antibodies (NAb) are important in immunity. This study aims to determine a connection between serum NAb titers, beta-hydroxybutyr...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Veterinary World
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167533/ https://www.ncbi.nlm.nih.gov/pubmed/34083952 http://dx.doi.org/10.14202/vetworld.2021.1002-1006 |
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author | Kaçar, Cihan Kaya, Semra Kuru, Mushap Erkılıç, Ekin Emre Öğün, Metin Oral, Hasan Demir, Murat Can |
author_facet | Kaçar, Cihan Kaya, Semra Kuru, Mushap Erkılıç, Ekin Emre Öğün, Metin Oral, Hasan Demir, Murat Can |
author_sort | Kaçar, Cihan |
collection | PubMed |
description | BACKGROUND AND AIM: Many metabolic and immunological changes occur during the transition period. Innate immunity plays an important role against to infections and natural antibodies (NAb) are important in immunity. This study aims to determine a connection between serum NAb titers, beta-hydroxybutyric acid (BHBA), and non-esterified fatty acid (NEFA) concentrations in Tuj and Hemşin sheep during the peripartum period. MATERIALS AND METHODS: Serum NAb, BHBA, and NEFA levels were determined from the blood samples collected from Tuj and Hemşin sheep on days 30 and 15 before birth, on the day of birth (day 0), and on days 15 and 30 after birth. RESULTS: NAb titers were found to be higher in Tuj than in Hemşin sheep (p<0.001). No statistically significant difference was found in serum BHBA concentrations of both breeds on all sampling days (p>0.05). The serum NEFA level was lower in Tuj sheep in the last 15 days of pregnancy compared to Hemşin sheep (p<0.05), while no difference was found in samples collected at the other time points. CONCLUSION: This study indicated that serum NAb titers significantly changed in Tuj and Hemşin sheep during the transition period. Serum BHBA and NEFA concentrations increased during the last stages of pregnancy and decreased after birth. Based on these findings, it is suggested that the immunological status could vary by the breed of sheep or various factors that affect the sheep’s metabolic state. |
format | Online Article Text |
id | pubmed-8167533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Veterinary World |
record_format | MEDLINE/PubMed |
spelling | pubmed-81675332021-06-02 Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep Kaçar, Cihan Kaya, Semra Kuru, Mushap Erkılıç, Ekin Emre Öğün, Metin Oral, Hasan Demir, Murat Can Vet World Research Article BACKGROUND AND AIM: Many metabolic and immunological changes occur during the transition period. Innate immunity plays an important role against to infections and natural antibodies (NAb) are important in immunity. This study aims to determine a connection between serum NAb titers, beta-hydroxybutyric acid (BHBA), and non-esterified fatty acid (NEFA) concentrations in Tuj and Hemşin sheep during the peripartum period. MATERIALS AND METHODS: Serum NAb, BHBA, and NEFA levels were determined from the blood samples collected from Tuj and Hemşin sheep on days 30 and 15 before birth, on the day of birth (day 0), and on days 15 and 30 after birth. RESULTS: NAb titers were found to be higher in Tuj than in Hemşin sheep (p<0.001). No statistically significant difference was found in serum BHBA concentrations of both breeds on all sampling days (p>0.05). The serum NEFA level was lower in Tuj sheep in the last 15 days of pregnancy compared to Hemşin sheep (p<0.05), while no difference was found in samples collected at the other time points. CONCLUSION: This study indicated that serum NAb titers significantly changed in Tuj and Hemşin sheep during the transition period. Serum BHBA and NEFA concentrations increased during the last stages of pregnancy and decreased after birth. Based on these findings, it is suggested that the immunological status could vary by the breed of sheep or various factors that affect the sheep’s metabolic state. Veterinary World 2021-04 2021-04-26 /pmc/articles/PMC8167533/ /pubmed/34083952 http://dx.doi.org/10.14202/vetworld.2021.1002-1006 Text en Copyright: © Kaçar, et al. https://creativecommons.org/licenses/by/4.0/Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Kaçar, Cihan Kaya, Semra Kuru, Mushap Erkılıç, Ekin Emre Öğün, Metin Oral, Hasan Demir, Murat Can Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep |
title | Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep |
title_full | Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep |
title_fullStr | Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep |
title_full_unstemmed | Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep |
title_short | Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep |
title_sort | determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum tuj and hemşin sheep |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167533/ https://www.ncbi.nlm.nih.gov/pubmed/34083952 http://dx.doi.org/10.14202/vetworld.2021.1002-1006 |
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