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Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh

Bangladesh is an endemic region of dengue fever and experienced an unprecedented large outbreak with more than 100,000 confirmed cases in 2019. To understand the prevalence of dengue antibody in patients and molecular epidemiological characteristics of dengue virus (DENV) in this outbreak, a total o...

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Autores principales: Titir, Snigdha Rahman, Paul, Shyamal Kumar, Ahmed, Salma, Haque, Nazia, Nasreen, Syeda Anjuman, Hossain, Khondoker Shoaib, Ahmad, Fahim Uddin, Nila, Sultana Shabnam, Khanam, Jobyda, Nowsher, Neaz, Al Amin, Abu Mohammod Mayeenuddin, Khan, Amdad Ullah, Aung, Meiji Soe, Kobayashi, Nobumichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167647/
https://www.ncbi.nlm.nih.gov/pubmed/33919249
http://dx.doi.org/10.3390/tropicalmed6020058
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author Titir, Snigdha Rahman
Paul, Shyamal Kumar
Ahmed, Salma
Haque, Nazia
Nasreen, Syeda Anjuman
Hossain, Khondoker Shoaib
Ahmad, Fahim Uddin
Nila, Sultana Shabnam
Khanam, Jobyda
Nowsher, Neaz
Al Amin, Abu Mohammod Mayeenuddin
Khan, Amdad Ullah
Aung, Meiji Soe
Kobayashi, Nobumichi
author_facet Titir, Snigdha Rahman
Paul, Shyamal Kumar
Ahmed, Salma
Haque, Nazia
Nasreen, Syeda Anjuman
Hossain, Khondoker Shoaib
Ahmad, Fahim Uddin
Nila, Sultana Shabnam
Khanam, Jobyda
Nowsher, Neaz
Al Amin, Abu Mohammod Mayeenuddin
Khan, Amdad Ullah
Aung, Meiji Soe
Kobayashi, Nobumichi
author_sort Titir, Snigdha Rahman
collection PubMed
description Bangladesh is an endemic region of dengue fever and experienced an unprecedented large outbreak with more than 100,000 confirmed cases in 2019. To understand the prevalence of dengue antibody in patients and molecular epidemiological characteristics of dengue virus (DENV) in this outbreak, a total of 179 blood samples were collected from patients in 10 districts (seven divisions) covering nearly the whole country from August to December 2019. DENV NS-1 was detected in 162 samples, among which DENV-specific IgM was positive in 119 samples (73.5%), including 60.5% samples also positive for DENV-specific IgG. Sequencing of the partial C-prM gene and its phylogenetic analysis revealed predominance of DENV type 3 genotype I, accounting for 93% of samples examined. DENV-3 genotype III was identified in two samples from separate districts, and only one DENV-2 cosmopolitan genotype was found in the capital city, Dhaka. These findings suggest the predominance of DENV-3 genotype I and occurrence of DENV-3 genotype III, associated with increased incidence of recent secondary infection in Bangladesh in 2019.
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spelling pubmed-81676472021-06-02 Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh Titir, Snigdha Rahman Paul, Shyamal Kumar Ahmed, Salma Haque, Nazia Nasreen, Syeda Anjuman Hossain, Khondoker Shoaib Ahmad, Fahim Uddin Nila, Sultana Shabnam Khanam, Jobyda Nowsher, Neaz Al Amin, Abu Mohammod Mayeenuddin Khan, Amdad Ullah Aung, Meiji Soe Kobayashi, Nobumichi Trop Med Infect Dis Communication Bangladesh is an endemic region of dengue fever and experienced an unprecedented large outbreak with more than 100,000 confirmed cases in 2019. To understand the prevalence of dengue antibody in patients and molecular epidemiological characteristics of dengue virus (DENV) in this outbreak, a total of 179 blood samples were collected from patients in 10 districts (seven divisions) covering nearly the whole country from August to December 2019. DENV NS-1 was detected in 162 samples, among which DENV-specific IgM was positive in 119 samples (73.5%), including 60.5% samples also positive for DENV-specific IgG. Sequencing of the partial C-prM gene and its phylogenetic analysis revealed predominance of DENV type 3 genotype I, accounting for 93% of samples examined. DENV-3 genotype III was identified in two samples from separate districts, and only one DENV-2 cosmopolitan genotype was found in the capital city, Dhaka. These findings suggest the predominance of DENV-3 genotype I and occurrence of DENV-3 genotype III, associated with increased incidence of recent secondary infection in Bangladesh in 2019. MDPI 2021-04-21 /pmc/articles/PMC8167647/ /pubmed/33919249 http://dx.doi.org/10.3390/tropicalmed6020058 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Titir, Snigdha Rahman
Paul, Shyamal Kumar
Ahmed, Salma
Haque, Nazia
Nasreen, Syeda Anjuman
Hossain, Khondoker Shoaib
Ahmad, Fahim Uddin
Nila, Sultana Shabnam
Khanam, Jobyda
Nowsher, Neaz
Al Amin, Abu Mohammod Mayeenuddin
Khan, Amdad Ullah
Aung, Meiji Soe
Kobayashi, Nobumichi
Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh
title Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh
title_full Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh
title_fullStr Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh
title_full_unstemmed Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh
title_short Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh
title_sort nationwide distribution of dengue virus type 3 (denv-3) genotype i and emergence of denv-3 genotype iii during the 2019 outbreak in bangladesh
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167647/
https://www.ncbi.nlm.nih.gov/pubmed/33919249
http://dx.doi.org/10.3390/tropicalmed6020058
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