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Tumor-Treating Fields Therapy for Pediatric Brain Tumors

Tumor-treating fields (TTFields) are alternating electric fields applied continuously to the brain by attaching two-pair arrays on the scalp. Although TTFields therapy has demonstrated efficacy against supratentorial glioblastoma (GBM) in adults, its safety and efficacy in children have not been con...

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Autores principales: Makimoto, Atsushi, Nishikawa, Ryo, Terashima, Keita, Kurihara, Jun, Fujisaki, Hiroyuki, Ihara, Satoshi, Morikawa, Yoshihiko, Yuza, Yuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167650/
https://www.ncbi.nlm.nih.gov/pubmed/33917660
http://dx.doi.org/10.3390/neurolint13020015
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author Makimoto, Atsushi
Nishikawa, Ryo
Terashima, Keita
Kurihara, Jun
Fujisaki, Hiroyuki
Ihara, Satoshi
Morikawa, Yoshihiko
Yuza, Yuki
author_facet Makimoto, Atsushi
Nishikawa, Ryo
Terashima, Keita
Kurihara, Jun
Fujisaki, Hiroyuki
Ihara, Satoshi
Morikawa, Yoshihiko
Yuza, Yuki
author_sort Makimoto, Atsushi
collection PubMed
description Tumor-treating fields (TTFields) are alternating electric fields applied continuously to the brain by attaching two-pair arrays on the scalp. Although TTFields therapy has demonstrated efficacy against supratentorial glioblastoma (GBM) in adults, its safety and efficacy in children have not been confirmed. Despite differences in the genetic etiology of the adult and pediatric forms of GBM, both have certain clinical behaviors in common, allowing us to test TTFields therapy in pediatric GBM. Recently, several, pediatric case-series using TTFields therapy have been published, and a few, prospective, pediatric studies are ongoing. Because GBMs are extremely rare in pediatric patients, where they comprise a wide variety of genetic subtypes, these pediatric studies are feasibility studies targeting various types of malignant brain tumor. Although they are important for confirming the safety and feasibility of TTFields therapy in the pediatric population, confirming its efficacy against each type of pediatric brain tumor, including the GBM, is difficult. Our clinical research team, therefore, planned an investigator-initiated clinical trial targeting pediatric supratentorial GBMs (as in adults) with the aim of expanding regulatory approval of TTFields therapy for pediatric GBM treatment based on safety and exploratory efficacy data in combination with the accumulated evidence on adult GBMs.
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spelling pubmed-81676502021-06-02 Tumor-Treating Fields Therapy for Pediatric Brain Tumors Makimoto, Atsushi Nishikawa, Ryo Terashima, Keita Kurihara, Jun Fujisaki, Hiroyuki Ihara, Satoshi Morikawa, Yoshihiko Yuza, Yuki Neurol Int Review Tumor-treating fields (TTFields) are alternating electric fields applied continuously to the brain by attaching two-pair arrays on the scalp. Although TTFields therapy has demonstrated efficacy against supratentorial glioblastoma (GBM) in adults, its safety and efficacy in children have not been confirmed. Despite differences in the genetic etiology of the adult and pediatric forms of GBM, both have certain clinical behaviors in common, allowing us to test TTFields therapy in pediatric GBM. Recently, several, pediatric case-series using TTFields therapy have been published, and a few, prospective, pediatric studies are ongoing. Because GBMs are extremely rare in pediatric patients, where they comprise a wide variety of genetic subtypes, these pediatric studies are feasibility studies targeting various types of malignant brain tumor. Although they are important for confirming the safety and feasibility of TTFields therapy in the pediatric population, confirming its efficacy against each type of pediatric brain tumor, including the GBM, is difficult. Our clinical research team, therefore, planned an investigator-initiated clinical trial targeting pediatric supratentorial GBMs (as in adults) with the aim of expanding regulatory approval of TTFields therapy for pediatric GBM treatment based on safety and exploratory efficacy data in combination with the accumulated evidence on adult GBMs. MDPI 2021-04-08 /pmc/articles/PMC8167650/ /pubmed/33917660 http://dx.doi.org/10.3390/neurolint13020015 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Makimoto, Atsushi
Nishikawa, Ryo
Terashima, Keita
Kurihara, Jun
Fujisaki, Hiroyuki
Ihara, Satoshi
Morikawa, Yoshihiko
Yuza, Yuki
Tumor-Treating Fields Therapy for Pediatric Brain Tumors
title Tumor-Treating Fields Therapy for Pediatric Brain Tumors
title_full Tumor-Treating Fields Therapy for Pediatric Brain Tumors
title_fullStr Tumor-Treating Fields Therapy for Pediatric Brain Tumors
title_full_unstemmed Tumor-Treating Fields Therapy for Pediatric Brain Tumors
title_short Tumor-Treating Fields Therapy for Pediatric Brain Tumors
title_sort tumor-treating fields therapy for pediatric brain tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167650/
https://www.ncbi.nlm.nih.gov/pubmed/33917660
http://dx.doi.org/10.3390/neurolint13020015
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