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A review of acute limb ischemia in COVID-positive patients

This literature review discusses the current evidence on acute limb ischemia (ALI) in patients with COVID-19. Throughout the pandemic, these patients have been at increased risk of arterial thrombotic events and subsequent mortality as a result of a hypercoagulable state. The exact mechanism of thro...

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Autores principales: Ilonzo, Nicole, Judelson, Dejah, Al-Jundi, Wissam, Etkin, Yana, O'Banion, Leigh Anne, Rivera, Aksim, Tinelli, Giovanni, Bellosta, Rafaello, Vouyouka, Ageliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167656/
https://www.ncbi.nlm.nih.gov/pubmed/34144749
http://dx.doi.org/10.1053/j.semvascsurg.2021.04.004
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author Ilonzo, Nicole
Judelson, Dejah
Al-Jundi, Wissam
Etkin, Yana
O'Banion, Leigh Anne
Rivera, Aksim
Tinelli, Giovanni
Bellosta, Rafaello
Vouyouka, Ageliki
author_facet Ilonzo, Nicole
Judelson, Dejah
Al-Jundi, Wissam
Etkin, Yana
O'Banion, Leigh Anne
Rivera, Aksim
Tinelli, Giovanni
Bellosta, Rafaello
Vouyouka, Ageliki
author_sort Ilonzo, Nicole
collection PubMed
description This literature review discusses the current evidence on acute limb ischemia (ALI) in patients with COVID-19. Throughout the pandemic, these patients have been at increased risk of arterial thrombotic events and subsequent mortality as a result of a hypercoagulable state. The exact mechanism of thrombosis is unknown; however arterial thrombosis may be due to invasion of endothelial cells via angiotensin-converting enzyme 2 (ACE2) receptors, endothelial injury from inflammation, or even free-floating aortic thrombus. Multiple studies have been performed evaluating the medical and surgical management of these patients; the decision to proceed with operative intervention is dependent on the patient’s clinical status as it relates to COVID-19 and morbidity of that disease. The interventions afforded typically include anticoagulation in patients undergoing palliation; alternatively, thrombectomy (endovascular and open) is utilized in other patients. There is a high risk of rethrombosis, despite anticoagulation, given persistent endothelial injury from the virus. Postoperative mortality can be high in these patients.
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spelling pubmed-81676562021-06-01 A review of acute limb ischemia in COVID-positive patients Ilonzo, Nicole Judelson, Dejah Al-Jundi, Wissam Etkin, Yana O'Banion, Leigh Anne Rivera, Aksim Tinelli, Giovanni Bellosta, Rafaello Vouyouka, Ageliki Semin Vasc Surg Review Article This literature review discusses the current evidence on acute limb ischemia (ALI) in patients with COVID-19. Throughout the pandemic, these patients have been at increased risk of arterial thrombotic events and subsequent mortality as a result of a hypercoagulable state. The exact mechanism of thrombosis is unknown; however arterial thrombosis may be due to invasion of endothelial cells via angiotensin-converting enzyme 2 (ACE2) receptors, endothelial injury from inflammation, or even free-floating aortic thrombus. Multiple studies have been performed evaluating the medical and surgical management of these patients; the decision to proceed with operative intervention is dependent on the patient’s clinical status as it relates to COVID-19 and morbidity of that disease. The interventions afforded typically include anticoagulation in patients undergoing palliation; alternatively, thrombectomy (endovascular and open) is utilized in other patients. There is a high risk of rethrombosis, despite anticoagulation, given persistent endothelial injury from the virus. Postoperative mortality can be high in these patients. Elsevier Inc. 2021-06 2021-05-20 /pmc/articles/PMC8167656/ /pubmed/34144749 http://dx.doi.org/10.1053/j.semvascsurg.2021.04.004 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Ilonzo, Nicole
Judelson, Dejah
Al-Jundi, Wissam
Etkin, Yana
O'Banion, Leigh Anne
Rivera, Aksim
Tinelli, Giovanni
Bellosta, Rafaello
Vouyouka, Ageliki
A review of acute limb ischemia in COVID-positive patients
title A review of acute limb ischemia in COVID-positive patients
title_full A review of acute limb ischemia in COVID-positive patients
title_fullStr A review of acute limb ischemia in COVID-positive patients
title_full_unstemmed A review of acute limb ischemia in COVID-positive patients
title_short A review of acute limb ischemia in COVID-positive patients
title_sort review of acute limb ischemia in covid-positive patients
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167656/
https://www.ncbi.nlm.nih.gov/pubmed/34144749
http://dx.doi.org/10.1053/j.semvascsurg.2021.04.004
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