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Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions

Lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen associated with aseptic meningitis, severe systemic infections in immunocompromised persons, and congenital anomalies. Data on the prevalence of LCMV infections are scarce. We analyzed the seroprevalence of LCMV in continental C...

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Autores principales: Vilibic-Cavlek, Tatjana, Oreski, Tena, Korva, Misa, Kolaric, Branko, Stevanovic, Vladimir, Zidovec-Lepej, Snjezana, Tabain, Irena, Jelicic, Pavle, Miklausic-Pavic, Bozana, Savic, Vladimir, Barbic, Ljubo, Avsic-Zupanc, Tatjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167717/
https://www.ncbi.nlm.nih.gov/pubmed/33947040
http://dx.doi.org/10.3390/tropicalmed6020067
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author Vilibic-Cavlek, Tatjana
Oreski, Tena
Korva, Misa
Kolaric, Branko
Stevanovic, Vladimir
Zidovec-Lepej, Snjezana
Tabain, Irena
Jelicic, Pavle
Miklausic-Pavic, Bozana
Savic, Vladimir
Barbic, Ljubo
Avsic-Zupanc, Tatjana
author_facet Vilibic-Cavlek, Tatjana
Oreski, Tena
Korva, Misa
Kolaric, Branko
Stevanovic, Vladimir
Zidovec-Lepej, Snjezana
Tabain, Irena
Jelicic, Pavle
Miklausic-Pavic, Bozana
Savic, Vladimir
Barbic, Ljubo
Avsic-Zupanc, Tatjana
author_sort Vilibic-Cavlek, Tatjana
collection PubMed
description Lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen associated with aseptic meningitis, severe systemic infections in immunocompromised persons, and congenital anomalies. Data on the prevalence of LCMV infections are scarce. We analyzed the seroprevalence of LCMV in continental Croatian regions. A total of 338 serum samples of professionally exposed (forestry workers, hunters, agriculture workers in contact with rodents) and non-exposed populations (general population, pregnant women) were tested for the presence of LCMV antibodies using indirect immunofluorescence assay. No participants reported recent febrile disease. LCMV IgG antibodies were detected in 23/6.8% of participants: 9.8% exposed persons and 5.1% non-exposed persons (6.1% in the general population and 3.9% in pregnant women). No participants were LCMV IgM positive. Although higher seropositivity was found in males compared to females (8.9% vs. 4.7%), inhabitants of suburban/rural areas compared to inhabitants of urban areas (9.2% vs. 4.6%), and persons who used well as a source of water compared to those who used tap (11.4% vs. 5.6%), these differences did not reach statistical significance. Results of logistic regression showed that the presence of rodents in the house/yard and cleaning rodent nests were associated with an elevated risk for LCMV infection (OR = 2.962, 95% CI = 1.019–8.607).
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spelling pubmed-81677172021-06-02 Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions Vilibic-Cavlek, Tatjana Oreski, Tena Korva, Misa Kolaric, Branko Stevanovic, Vladimir Zidovec-Lepej, Snjezana Tabain, Irena Jelicic, Pavle Miklausic-Pavic, Bozana Savic, Vladimir Barbic, Ljubo Avsic-Zupanc, Tatjana Trop Med Infect Dis Article Lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen associated with aseptic meningitis, severe systemic infections in immunocompromised persons, and congenital anomalies. Data on the prevalence of LCMV infections are scarce. We analyzed the seroprevalence of LCMV in continental Croatian regions. A total of 338 serum samples of professionally exposed (forestry workers, hunters, agriculture workers in contact with rodents) and non-exposed populations (general population, pregnant women) were tested for the presence of LCMV antibodies using indirect immunofluorescence assay. No participants reported recent febrile disease. LCMV IgG antibodies were detected in 23/6.8% of participants: 9.8% exposed persons and 5.1% non-exposed persons (6.1% in the general population and 3.9% in pregnant women). No participants were LCMV IgM positive. Although higher seropositivity was found in males compared to females (8.9% vs. 4.7%), inhabitants of suburban/rural areas compared to inhabitants of urban areas (9.2% vs. 4.6%), and persons who used well as a source of water compared to those who used tap (11.4% vs. 5.6%), these differences did not reach statistical significance. Results of logistic regression showed that the presence of rodents in the house/yard and cleaning rodent nests were associated with an elevated risk for LCMV infection (OR = 2.962, 95% CI = 1.019–8.607). MDPI 2021-04-29 /pmc/articles/PMC8167717/ /pubmed/33947040 http://dx.doi.org/10.3390/tropicalmed6020067 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vilibic-Cavlek, Tatjana
Oreski, Tena
Korva, Misa
Kolaric, Branko
Stevanovic, Vladimir
Zidovec-Lepej, Snjezana
Tabain, Irena
Jelicic, Pavle
Miklausic-Pavic, Bozana
Savic, Vladimir
Barbic, Ljubo
Avsic-Zupanc, Tatjana
Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions
title Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions
title_full Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions
title_fullStr Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions
title_full_unstemmed Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions
title_short Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions
title_sort prevalence and risk factors for lymphocytic choriomeningitis virus infection in continental croatian regions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167717/
https://www.ncbi.nlm.nih.gov/pubmed/33947040
http://dx.doi.org/10.3390/tropicalmed6020067
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