The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin

Oncogenic histone lysine-to-methionine mutations block the methylation of their corresponding lysine residues on wild-type histones. One attractive model is that these mutations sequester histone methyltransferases, but genome-wide studies show that mutant histones and histone methyltransferases oft...

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Detalles Bibliográficos
Autores principales: Shan, Chun-Min, Kim, Jin-Kwang, Wang, Jiyong, Bao, Kehan, Sun, Yadong, Chen, Huijie, Yue, Jia-Xing, Stirpe, Alessandro, Zhang, Zhiguo, Lu, Chao, Schalch, Thomas, Liti, Gianni, Nagy, Peter L., Tong, Liang, Qiao, Feng, Jia, Songtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167812/
https://www.ncbi.nlm.nih.gov/pubmed/34010645
http://dx.doi.org/10.1016/j.celrep.2021.109137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167812/
https://www.ncbi.nlm.nih.gov/pubmed/34010645
http://dx.doi.org/10.1016/j.celrep.2021.109137

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