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Subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex

Nervous systems maintain information internally using persistent activity changes. The mechanisms by which this activity arises are incompletely understood. We study prefrontal cortex (PFC) in mice performing behaviors in which stimuli predicted rewards at different delays with different probabiliti...

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Detalles Bibliográficos
Autores principales: Kim, Eunyoung, Bari, Bilal A., Cohen, Jeremiah Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167820/
https://www.ncbi.nlm.nih.gov/pubmed/33951442
http://dx.doi.org/10.1016/j.celrep.2021.109082
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author Kim, Eunyoung
Bari, Bilal A.
Cohen, Jeremiah Y.
author_facet Kim, Eunyoung
Bari, Bilal A.
Cohen, Jeremiah Y.
author_sort Kim, Eunyoung
collection PubMed
description Nervous systems maintain information internally using persistent activity changes. The mechanisms by which this activity arises are incompletely understood. We study prefrontal cortex (PFC) in mice performing behaviors in which stimuli predicted rewards at different delays with different probabilities. We measure membrane potential (V(m)) from pyramidal neurons across layers. Reward-predictive persistent firing increases arise due to sustained increases in mean and variance of V(m) and are terminated by reward or via centrally generated mechanisms based on reward expectation. Other neurons show persistent decreases in firing rates, maintained by persistent hyperpolarization that is robust to intracellular perturbation. Persistent activity is layer (L)- and cell-type-specific. Neurons with persistent depolarization are primarily located in upper L5, whereas those with persistent hyperpolarization are mostly found in lower L5. L2/3 neurons do not show persistent activity. Thus, reward-predictive persistent activity in PFC is spatially organized and conveys information about internal state via synaptic mechanisms.
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spelling pubmed-81678202021-06-01 Subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex Kim, Eunyoung Bari, Bilal A. Cohen, Jeremiah Y. Cell Rep Article Nervous systems maintain information internally using persistent activity changes. The mechanisms by which this activity arises are incompletely understood. We study prefrontal cortex (PFC) in mice performing behaviors in which stimuli predicted rewards at different delays with different probabilities. We measure membrane potential (V(m)) from pyramidal neurons across layers. Reward-predictive persistent firing increases arise due to sustained increases in mean and variance of V(m) and are terminated by reward or via centrally generated mechanisms based on reward expectation. Other neurons show persistent decreases in firing rates, maintained by persistent hyperpolarization that is robust to intracellular perturbation. Persistent activity is layer (L)- and cell-type-specific. Neurons with persistent depolarization are primarily located in upper L5, whereas those with persistent hyperpolarization are mostly found in lower L5. L2/3 neurons do not show persistent activity. Thus, reward-predictive persistent activity in PFC is spatially organized and conveys information about internal state via synaptic mechanisms. 2021-05-04 /pmc/articles/PMC8167820/ /pubmed/33951442 http://dx.doi.org/10.1016/j.celrep.2021.109082 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license.
spellingShingle Article
Kim, Eunyoung
Bari, Bilal A.
Cohen, Jeremiah Y.
Subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex
title Subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex
title_full Subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex
title_fullStr Subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex
title_full_unstemmed Subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex
title_short Subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex
title_sort subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167820/
https://www.ncbi.nlm.nih.gov/pubmed/33951442
http://dx.doi.org/10.1016/j.celrep.2021.109082
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