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A hydrophobic ratchet entrenches molecular complexes
Most proteins assemble into multisubunit complexes(1). The persistence of these complexes across evolutionary time is usually explained as the result of natural selection for functional properties that depend upon multimerization, like intersubunit allostery or the capacity to do mechanical work(2)....
Autores principales: | Hochberg, Georg K.A., Liu, Yang, Marklund, Erik G., Metzger, Brian P. H., Laganowsky, Arthur, Thornton, Joseph W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168016/ https://www.ncbi.nlm.nih.gov/pubmed/33299178 http://dx.doi.org/10.1038/s41586-020-3021-2 |
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