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A hydrophobic ratchet entrenches molecular complexes

Most proteins assemble into multisubunit complexes(1). The persistence of these complexes across evolutionary time is usually explained as the result of natural selection for functional properties that depend upon multimerization, like intersubunit allostery or the capacity to do mechanical work(2)....

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Detalles Bibliográficos
Autores principales: Hochberg, Georg K.A., Liu, Yang, Marklund, Erik G., Metzger, Brian P. H., Laganowsky, Arthur, Thornton, Joseph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168016/
https://www.ncbi.nlm.nih.gov/pubmed/33299178
http://dx.doi.org/10.1038/s41586-020-3021-2

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