HGG-09. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION IN DIPG

DIPG is an aggressive and incurable childhood brain tumour for which new treatments are needed. A high throughput drug screen of 3500 pharmaceutical compounds identified anti-malarials, including quinacrine as having potent activity against DIPG neurospheres. CBL0137, a compound modelled on quinacri...

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Detalles Bibliográficos
Autores principales: Ehteda, Anahid, Simon, Sandy, Franshaw, Laura, Giorgi, Federico M, Liu, Jie, Hayden, Elisha, Rouaen, Jourdin, Pang, Chi Nam Ignatius, Pandher, Ruby, Mayoh, Chelsea, Tang, Yujie, Khan, Aaminah, Ung, Caitlin, Kankean, Anne, Lehmann, Rebecca, Shen, Sylvie, Gopalakrishnan, Anjana, Trebilcock, Peter, Gurova, Katerina, Gudkov, Andrei, Norris, Murray D, Haber, Michelle, Vittorio, Orazio, Tsoli, Maria, Ziegler, David S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
High Grade Gliomas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168074/
http://dx.doi.org/10.1093/neuonc/noab090.075

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