HGG-25. PRMT5 PROMOTES TUMOR GROWTH BY MAINTAINING STEMNESS OF PEDIATRIC HIGH-GRADE GLIOMA CELLS

BACKGROUND: Pediatric high-grade gliomas (pHGG) are aggressive tumors that together constitute the most common cause of childhood cancer mortality. Tumor stem cells that drive proliferation of pHGG resist chemotherapy and radiation, complicating treatment. The arginine methyltransferase PRMT5 mainta...

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Detalles Bibliográficos
Autores principales: DeSisto, John, Knox, Aaron, Chatwin, Hannah, Balakrishnan, Ilango, Venkataraman, Sujatha, Vibhakar, Rajeev, Green, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
High Grade Gliomas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168078/
http://dx.doi.org/10.1093/neuonc/noab090.089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168078/
http://dx.doi.org/10.1093/neuonc/noab090.089

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