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ATRT-02. THE DUAL MTORC1/2 INHIBITOR, TAK-228 COMBINES SYNERGISTICALLY WITH THE BH3 MIMETIC, OBATOCLAX TO IMPROVE SURVIVAL IN MICE BEARING ORTHOTOPIC XENOGRAFTS OF AT/RT

mTOR activation drives tumorigenicity by regulating transcription factor expression and downstream growth and survival pathways. We have previously shown that mTORC1 and mTORC2 are highly activated in AT/RT and the dual mTORC1/2 inhibitor, TAK-228 (Sapanisertib) improves survival in mice bearing ort...

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Detalles Bibliográficos
Autores principales:	Findlay, Tyler, Parkhurst, Ashlyn, Wang, Sabrina, Eberhart, Charles, Raabe, Eric, Rubens, Jeffrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Atypical Teratoid Rhabdoid Tumors
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168110/ http://dx.doi.org/10.1093/neuonc/noab090.002

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