HGG-06. EARLY GABAERGIC NEURONAL LINEAGE DEFINES DEPENDENCIES IN HISTONE H3 G34R/V GLIOMA

High-grade gliomas harboring H3 G34R/V mutations exclusively occur in the cerebral hemispheres of adolescents and young adults, suggesting a distinct neurodevelopmental origin. Combining multimodal bulk and single-cell genomics with unbiased genome-scale CRISPR/Cas9 approaches, we here describe a GA...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Ilon, Bjerke, Lynn, Cruzeiro, Gustavo Alencastro Veiga, Rogers, Rebecca F, Grabovska, Yura, Panditharatna, Eshini, Mackay, Alan, Barron, Tara, Shaw, McKenzie, Hoffman, Samantha E, Hack, Olivia A, Quezada, Michael A, Dempster, Joshua, Temelso, Sara, Englinger, Bernhard, Molinari, Valeria, Mire, Hafsa M, Jiang, Li, Madlener, Sibylle, Mayr, Lisa, Dorfer, Christian, Geyeregger, Rene, Rota, Christopher, Ricken, Gerda, Alexandrescu, Sanda, Braun, Emelie, Danan-Gotthold, Miri, Hu, Lijuan, Siletti, Kimberly, Sundstroem, Erik, Hodge, Rebecca, Lein, Ed, Agnihotri, Sameer, Eisenstat, David D, Carceller, Fernando, Stapleton, Simon, Bleil, Cristina, Mastronuzzi, Angela, Cole, Kristina A, Waanders, Angela J, Carcaboso, Angel Montero, Vinci, Maria, Hargrave, Darren, Haberler, Christine, Gojo, Johannes, Slavc, Irene, Linnarsson, Sten, Monje, Michelle, Jones, Chris, Filbin, Mariella G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
High Grade Gliomas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168148/
http://dx.doi.org/10.1093/neuonc/noab090.072

Ejemplares similares

Ejemplares similares