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HGG-30. BRAIN PENETRANT HDAC INHIBITOR RG2833 SYNERGIZES WITH LOMUSTINE AND RADIATION TO INDUCE DIPG CELL DEATH

Diffuse intrinsic pontine glioma (DIPG) is driven by epigenetic dysregulation. The pan-HDAC inhibitor panobinostat showed pre-clinical efficacy against DIPG, but was limited by toxicity in clinical trials. RG2833 (RGFP109) is a selective HDAC1/3 inhibitor with established brain penetration. RG2833 r...

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Detalles Bibliográficos
Autores principales:	Barnett, Katherine, Novak, Orlandi, Eberhart, Charles, Raabe, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	High Grade Gliomas
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168179/ http://dx.doi.org/10.1093/neuonc/noab090.094

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