EPCT-09. CNS LEVELS OF PANOBINOSTAT IN A NON-HUMAN PRIMATE MODEL: COMPARISON OF BLOOD AND CEREBROSPINAL FLUID PHARMACOKINETIC METHODS AND MALDI MSI

Adequate exposure (effective concentration over time) of a therapeutic agent at its site of action is essential for antitumor efficacy. Given constraints of repeat tissue sampling, non-human primate models predictive of pharmacokinetics in pediatric patients have been utilized to assess central nerv...

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Detalles Bibliográficos
Autores principales: Warren, Katherine, McCully, Cynthia Lester, Garcia, Rafael Cruz, Stopka, Sylwia, Regan, Michael, Aye, Thet, Zimmerman, Sara, Peer, Cody, Kramer, Josh, Breed, Matthew, Figg, W Douglas, Agar, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Translational/Early Phase Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168181/
http://dx.doi.org/10.1093/neuonc/noab090.195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168181/
http://dx.doi.org/10.1093/neuonc/noab090.195

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